Rapamune and Effexor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rapamune (sirolimus) and Effexor (venlafaxine hydrochloride). Common drug interactions include blood urea increased among females and antidepressant drug level increased among males.

The phase IV clinical study analyzes what interactions people have when they take Rapamune and Effexor. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,493 Effexor users. Check the latest studies of Effexor.

On Jul, 11, 2026

30 people who take Rapamune and Effexor together, and have interactions are studied.

What are the common drug interactions of Rapamune and Effexor, by gender? *:

female:

Blood urea increased
Breast cancer recurrent
Conjunctivitis (pink eye)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug level increased
Dry eye (lack of adequate tears)
Haematocrit decreased
Haemoglobin decreased
Hepatitis acute
Infection

male:

Antidepressant drug level increased
Arterial disorder
Infection
Laceration (tearing of soft body tissue)
Lymphangitis (inflammation of the lymph channel)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pyrexia (fever)
Renal failure (kidney dysfunction)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Sinusitis (inflammation of sinus)

What are the common drug interactions of Rapamune and Effexor, by age (0-1 to 60+)? *:

0-1:

Arterial disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Cellulitis (infection under the skin)
Chest pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Fracture
Infection
Laceration (tearing of soft body tissue)

2-9:

n/a

10-19:

n/a

20-29:

Sleep disorder

30-39:

Asthenia (weakness)
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal pain upper
Non-cardiac chest pain
Abdominal pain
Chest pain
Conjunctivitis (pink eye)
Dry eye (lack of adequate tears)
Ocular rosacea (redness, irritation or burning of the eyes)
Renal failure acute (rapid kidney dysfunction)

40-49:

Death

50-59:

Subcutaneous abscess
Syncope (loss of consciousness with an inability to maintain postural tone)
Toothache (tooth pain)
Ureteral disorder
Visual impairment
Vomiting
Diarrhoea
Abdominal pain
Overdose
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)

60+:

Abdominal discomfort
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Renal failure acute (rapid kidney dysfunction)
Alcohol use
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Decreased appetite
Dry mouth
Faecal incontinence (a lack of control over passing stool)
Weight increased

What are the existing conditions these people have? *

Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 4 people, 13.33%
Squamous Cell Carcinoma (a cancer of a kind of epithelial cell): 4 people, 13.33%
Neuropathy Peripheral (surface nerve damage): 4 people, 13.33%
Tooth Fracture: 4 people, 13.33%
Immunodeficiency Disorders: 4 people, 13.33%
Bronchopulmonary Aspergillosis (lung disorder caused by aspergillus fungi): 3 people, 10.00%
High Blood Pressure: 3 people, 10.00%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 6.67%
Bone Loss: 2 people, 6.67%
Cough: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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