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Rasuvo and Rinvoq drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rasuvo (methotrexate) and Rinvoq (upadacitinib). Common drug interactions include hypoaesthesia among females and abscess oral among males.

The phase IV clinical study analyzes what interactions people have when they take Rasuvo and Rinvoq. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Rasuvo?

Rasuvo has active ingredients of methotrexate. It is often used in psoriatic arthritis. eHealthMe is studying from 3,702 Rasuvo users. Check the latest studies of Rasuvo.

What is Rinvoq?

Rinvoq has active ingredients of upadacitinib. eHealthMe is studying from 47,375 Rinvoq users. Check the latest studies of Rinvoq.

On Aug, 11, 2026

23 people who take Rasuvo and Rinvoq together, and have interactions are studied.

Rasuvo and Rinvoq drug interactions.

What are the common drug interactions of Rasuvo and Rinvoq, by gender? *:

female:

  1. Hypoaesthesia (reduced sense of touch or sensation)
  2. Pain
  3. Drug ineffective
  4. Dyspnoea (difficult or laboured respiration)
  5. Inflammatory marker increased
  6. Knee arthroplasty
  7. Procedural pain
  8. Back pain
  9. Fatigue (feeling of tiredness)
  10. Swelling

male:

  1. Abscess oral (abscess in the mouth)
  2. Adverse drug reaction
  3. Drug ineffective
  4. Eye pain
  5. Muscle spasms (muscle contraction)
  6. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  7. Neuropathy peripheral (surface nerve damage)
  8. Ocular hyperaemia (an abnormally large amount of blood in eye)

What are the common drug interactions of Rasuvo and Rinvoq, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Hypoaesthesia (reduced sense of touch or sensation)
  2. Pain
  3. Back pain
  4. Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
  5. Bone pain
  6. Crying
  7. Drug ineffective
  8. Dysstasia (difficulty in standing)
  9. Intervertebral disc protrusion (spinal disc protrusion)
  10. Limb injury

60+:

  1. Dyspnoea (difficult or laboured respiration)
  2. Arthralgia (joint pain)
  3. Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
  4. Hypertrophic cardiomyopathy (a condition in which the heart muscle becomes abnormally thick)
  5. Hypokinesia (decreased bodily movement)
  6. Hypoxia (low oxygen in tissues)
  7. Interstitial lung disease
  8. Joint stiffness
  9. Joint swelling
  10. Lower limb fracture

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 17 people, 73.91%
  2. High Blood Cholesterol: 3 people, 13.04%
  3. Stress And Anxiety: 2 people, 8.70%
  4. Depression: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Rasuvo and Rinvoq?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Rasuvo and Rinvoq:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Rasuvo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Rinvoq:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rasuvo and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rinvoq and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate and upadacitinib (the active ingredients of Rasuvo and Rinvoq, respectively), and Rasuvo and Rinvoq (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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