Rayos and Arava drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rayos (prednisone) and Arava (leflunomide). Common drug interactions include sinusitis among females.

The phase IV clinical study analyzes what interactions people have when they take Rayos and Arava. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Rayos?

Rayos has active ingredients of prednisone. It is often used in systemic lupus erythematosus. eHealthMe is studying from 896 Rayos users. Check the latest studies of Rayos.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

On Jul, 26, 2026

19 people who take Rayos and Arava together, and have interactions are studied.

What are the common drug interactions of Rayos and Arava, by gender? *:

female:

Sinusitis (inflammation of sinus)
Drug ineffective
Heart rate increased
Insomnia (sleeplessness)
Pain
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cellulitis (infection under the skin)
Cough

male:

n/a

What are the common drug interactions of Rayos and Arava, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Drug ineffective
Nausea (feeling of having an urge to vomit)
Vomiting

50-59:

Drug ineffective
Dyspnoea (difficult or laboured respiration)
Gait disturbance
Heart rate increased
Insomnia (sleeplessness)
Pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Influenza
Injection site pruritus (severe itching at injection site)

60+:

Cellulitis (infection under the skin)
Cough
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Sinusitis (inflammation of sinus)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Haematocrit decreased

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 5.26%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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