Reclast and Prograf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Reclast (zoledronic acid) and Prograf (tacrolimus). Common drug interactions include bone disorder among females and blood creatinine increased among males.

The phase IV clinical study analyzes what interactions people have when they take Reclast and Prograf. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Reclast?

Reclast has active ingredients of zoledronic acid. It is often used in osteoporosis. eHealthMe is studying from 15,774 Reclast users. Check the latest studies of Reclast.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

On Jul, 08, 2026

13 people who take Reclast and Prograf together, and have interactions are studied.

What are the common drug interactions of Reclast and Prograf, by gender? *:

female:

Bone disorder
Death
Nausea (feeling of having an urge to vomit)
Renal impairment (severely reduced kidney function)
Arthralgia (joint pain)
Asthenia (weakness)
Chills (felling of cold)
Cough
Lymphadenitis (inflammation or enlargement of a lymph node)
Myalgia (muscle pain)

male:

Blood creatinine increased
Alanine aminotransferase increased
Gamma-glutamyltransferase increased
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematocrit decreased
Haemoglobin decreased
Headache (pain in head)
Leukopenia (less number of white blood cells in blood)
Liver transplant rejection (failure of liver transplant)
Mean cell haemoglobin increased (more than normal haemoglobin per red blood cell in a sample of blood)

What are the common drug interactions of Reclast and Prograf, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Blood creatinine increased
Dizziness
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Headache (pain in head)
Leukopenia (less number of white blood cells in blood)

50-59:

Bone disorder
Chills (felling of cold)
Death
Lymphadenitis (inflammation or enlargement of a lymph node)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Renal impairment (severely reduced kidney function)
Abdominal distension
Acute phase reaction
Anaemia (lack of blood)

60+:

Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Diarrhoea
Drug intolerance (drug sensitivity)
Dry skin
Fatigue (feeling of tiredness)
Frequent bowel movements
Gamma-glutamyltransferase increased
Haematocrit decreased
Haemoglobin decreased

What are the existing conditions these people have? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 7.69%
Pancreatic Neuroendocrine Tumor: 1 person, 7.69%
Multiple Myeloma (cancer of the plasma cells): 1 person, 7.69%
Iron Overload: 1 person, 7.69%
Fungal Infection: 1 person, 7.69%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 7.69%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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