Reclast and Simponi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Reclast (zoledronic acid) and Simponi (golimumab). Common drug interactions include hepatitis c among females and insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Reclast and Simponi. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Reclast?

Reclast has active ingredients of zoledronic acid. It is often used in osteoporosis. eHealthMe is studying from 15,774 Reclast users. Check the latest studies of Reclast.

What is Simponi?

Simponi has active ingredients of golimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 86,328 Simponi users. Check the latest studies of Simponi.

On Jul, 24, 2026

40 people who take Reclast and Simponi together, and have interactions are studied.

What are the common drug interactions of Reclast and Simponi, by gender? *:

female:

Hepatitis c
Swelling
Urinary tract infection
Abdominal pain upper
Anxiety
Balance disorder
Contusion (a type of hematoma of tissue in which capillaries)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Fall
Herpes zoster

male:

Insomnia (sleeplessness)
Post procedural complication
Procedural pain
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Drug effect decreased
Drug ineffective
Palpitations (feelings or sensations that your heart is pounding or racing)
Psoriasis (immune-mediated disease that affects the skin)

What are the common drug interactions of Reclast and Simponi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Insomnia (sleeplessness)
Post procedural complication
Procedural pain
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Drug effect decreased
Drug ineffective
Palpitations (feelings or sensations that your heart is pounding or racing)
Psoriasis (immune-mediated disease that affects the skin)

50-59:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy
Asthenia (weakness)
Back pain
Constipation
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Dizziness
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Epigastric discomfort

60+:

Abdominal pain upper
Balance disorder
Furuncle (infection of the hair follicle)
Gastroenteritis (inflammation of stomach and intestine)
Hyperhidrosis (abnormally increased sweating)
Influenza like illness
Injection site reaction
Insomnia (sleeplessness)
Lung carcinoma cell type unspecified stage iv (the lung cancer has spread to other organs of the body, such as the other lung, brain, or liver)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

What are the existing conditions these people have? *

Pain: 6 people, 15.00%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 4 people, 10.00%
Seasonal Allergy (allergic condition due to certain season): 4 people, 10.00%
High Blood Pressure: 4 people, 10.00%
Diabetes: 4 people, 10.00%
Overdose: 3 people, 7.50%
Migraine Without Aura (headache without neurological problems): 2 people, 5.00%
Joint Pain: 2 people, 5.00%
Headache (pain in head): 2 people, 5.00%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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