Reglan and Actigall drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Reglan (metoclopramide hydrochloride) and Actigall (ursodiol). Common drug interactions include perirectal abscess among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Reglan and Actigall. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

What is Actigall?

Actigall has active ingredients of ursodiol. It is often used in gallstones. eHealthMe is studying from 2,162 Actigall users. Check the latest studies of Actigall.

On Jul, 07, 2026

68 people who take Reglan and Actigall together, and have interactions are studied.

What are the common drug interactions of Reglan and Actigall, by gender? *:

female:

Perirectal abscess
Death
Hypoxia (low oxygen in tissues)
Melaena (the passage of black, tarry stools)
Neutropenia (an abnormally low number of neutrophils)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Respiratory distress (difficulty in breathing)
Abdominal pain
Abdominal pain upper
Constipation

male:

Abdominal pain
Hepatic failure (liver failure)
Asthenia (weakness)
Depression
Dilatation ventricular
Dyspnoea (difficult or laboured respiration)
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Hypersensitivity
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Insomnia (sleeplessness)

What are the common drug interactions of Reglan and Actigall, by age (0-1 to 60+)? *:

0-1:

Arrhythmia (irregular heartbeat)
Cardiac disorder
Cardiac failure
Dyspnoea (difficult or laboured respiration)
Hepatic failure (liver failure)
Hyperhidrosis (abnormally increased sweating)
Hypersensitivity
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Lung disorder (lung disease)

2-9:

n/a

10-19:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

20-29:

Abdominal pain
Anaemia (lack of blood)
Anorectal varices haemorrhage (dilation of collateral submucousal vessels due to backflow in the veins of the rectum with massive bleeding)
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Blood lactic acid increased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Coagulopathy (blood's ability to clot is impaired)
Contusion (a type of hematoma of tissue in which capillaries)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)

30-39:

Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Neutropenia (an abnormally low number of neutrophils)
Red blood cell count decreased
White blood cell count decreased

40-49:

Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Abdominal pain
Abdominal pain upper
Anxiety
Balance disorder
Breast abscess
Breast cellulitis (spreading, acute inflammation of beast skin)
Chest pain
Constipation
Diarrhoea haemorrhagic (bloody diarrhoea)

50-59:

Pneumonia
Renal cyst (kidney cyst)
Sensation of foreign body
Type 2 diabetes mellitus
Vocal cord polyp
Abdominal discomfort
Abdominal pain lower
Abdominal pain upper
Acute respiratory failure
Agitation (state of anxiety or nervous excitement)

60+:

Perirectal abscess
Pleural effusion (water on the lungs)
Abdominal distension
Abdominal pain upper
Adverse drug reaction
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Back pain
Blood pressure systolic increased
Cardiac disorder
Cardiac flutter (abnormal heart rhythm)

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 9 people, 13.24%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 10.29%
Pain: 6 people, 8.82%
Pancreatic Insufficiency: 4 people, 5.88%
Insomnia (sleeplessness): 4 people, 5.88%
Dyspnea (difficult or laboured breathing): 4 people, 5.88%
Cystic Fibrosis Lung (fibrosis with cyst in the lung): 4 people, 5.88%
Constipation: 4 people, 5.88%
Asthma: 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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