Reglan and Caffeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Reglan (metoclopramide hydrochloride) and Caffeine (caffeine). Common drug interactions include abdominal discomfort among females and hospitalisation among males.

The phase IV clinical study analyzes what interactions people have when they take Reglan and Caffeine. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

What is Caffeine?

Caffeine has active ingredients of caffeine. It is often used in fatigue. eHealthMe is studying from 6,667 Caffeine users. Check the latest studies of Caffeine.

On Jul, 27, 2026

17 people who take Reglan and Caffeine together, and have interactions are studied.

What are the common drug interactions of Reglan and Caffeine, by gender? *:

female:

Abdominal discomfort
Decreased appetite
Diarrhoea
Drug hypersensitivity
Headache (pain in head)
Pregnancy
Weight decreased
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Adrenal mass
Adverse drug reaction

male:

Hospitalisation
Anxiety
Hypersensitivity
Maternal exposure before pregnancy (use of substance before pregnancy)
Maternal exposure during pregnancy (use of substance during pregnancy)
Dyslipidaemia (abnormal amount of lipids)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Impaired gastric emptying
Loss of consciousness
Upper limb fracture

What are the common drug interactions of Reglan and Caffeine, by age (0-1 to 60+)? *:

0-1:

Haemangioma (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Hydrocele
Maternal exposure before pregnancy (use of substance before pregnancy)
Maternal exposure during pregnancy (use of substance during pregnancy)

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Adrenal mass
Adverse drug reaction
Anxiety
Blood testosterone free increased
Decreased appetite
Derealisation
Diarrhoea
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)

30-39:

Pregnancy
Pulmonary embolism (blockage of the main artery of the lung)
Abdominal discomfort
Abdominal pain
Abdominal pain upper
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Butterfly rash
Chills (felling of cold)
Decreased appetite
Dehydration (dryness resulting from the removal of water)

40-49:

Hospitalisation
Anxiety
Dyslipidaemia (abnormal amount of lipids)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Impaired gastric emptying
Loss of consciousness
Upper limb fracture
Weight decreased
Hypersensitivity

50-59:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Osteoporosis (bones weak and more likely to break)
Plicated tongue
Radial nerve injury
Rectal prolapse (falling of rectum from normal place)
Restless legs syndrome (a powerful urge to move your legs)
Rosacea (a skin condition that causes facial redness)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Spinal compression fracture (fracture due to spinal compression on bone)
Ulnar nerve injury

60+:

Drug hypersensitivity

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 5 people, 29.41%
Migraine (headache): 5 people, 29.41%
Indigestion: 4 people, 23.53%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 17.65%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 17.65%
Headache (pain in head): 3 people, 17.65%
Appetite Disorder (abnormal eating habits): 2 people, 11.76%
Sleep Disorder: 2 people, 11.76%
Insomnia (sleeplessness): 2 people, 11.76%
Drowsiness: 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

Do you take Reglan and Caffeine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously