Reglan and Glynase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Reglan (metoclopramide hydrochloride) and Glynase (glyburide). Common drug interactions include pulmonary oedema among females and hepatic necrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Reglan and Glynase. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

What is Glynase?

Glynase has active ingredients of glyburide. eHealthMe is studying from 1,513 Glynase users. Check the latest studies of Glynase.

On Jul, 10, 2026

19 people who take Reglan and Glynase together, and have interactions are studied.

What are the common drug interactions of Reglan and Glynase, by gender? *:

female:

Pulmonary oedema (fluid accumulation in the lungs)
Sedation
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Urine discolouration
Weakness
Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Blood bilirubin increased

male:

Hepatic necrosis (large portions of liver die off due to severe liver disease)
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Mallory-weiss syndrome (gastro-oesophageal laceration syndrome refers to bleeding from tears)
Oesophageal varices (extremely dilated sub-mucosal veins in the lower third of the oesophagus)
Cardiomegaly (increased size of heart than normal)
Colonic polyp (extra part of colon tissue grow in intestine)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastric erosions (gradual destruction of surface layer of the membrane lining the stomach)
Gastrointestinal motility disorder (abnormal intestinal contractions)
Haematemesis (vomiting of blood)

What are the common drug interactions of Reglan and Glynase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Asthenia (weakness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Cardiac disorder
Cardiac failure chronic
Cardiac valve disease (heart valve disease)
Cardiomyopathy (weakening of the heart muscle)
Cellulitis (infection under the skin)

50-59:

Chest pressure sensation (feeling of pressure on chest)
Confusion
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diarrhoea
Dyspepsia (indigestion)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fatigue (feeling of tiredness)
Headache (pain in head)
Hepatomegaly (abnormal enlargement of the liver)
Hypertension (high blood pressure)

60+:

Hepatic necrosis (large portions of liver die off due to severe liver disease)
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Mallory-weiss syndrome (gastro-oesophageal laceration syndrome refers to bleeding from tears)
Oesophageal varices (extremely dilated sub-mucosal veins in the lower third of the oesophagus)
Asthenia (weakness)
Cardiomegaly (increased size of heart than normal)
Colonic polyp (extra part of colon tissue grow in intestine)
Constipation
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

What are the existing conditions these people have? *

Diabetes: 3 people, 15.79%
Menopause (end of monthly cycles in women): 2 people, 10.53%
High Blood Pressure: 2 people, 10.53%
Vaginal Bleeding: 2 people, 10.53%
Indigestion: 1 person, 5.26%
Arrhythmias (irregular heartbeat): 1 person, 5.26%
Constipation: 1 person, 5.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.26%
Headache (pain in head): 1 person, 5.26%
Ventricular Extrasystoles (premature cardiac contraction): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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