Reglan and Hyzaar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Reglan (metoclopramide hydrochloride) and Hyzaar (hydrochlorothiazide; losartan potassium). Common drug interactions include anaemia among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Reglan and Hyzaar. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

What is Hyzaar?

Hyzaar has active ingredients of hydrochlorothiazide; losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 16,614 Hyzaar users. Check the latest studies of Hyzaar.

On Jul, 12, 2026

77 people who take Reglan and Hyzaar together, and have interactions are studied.

What are the common drug interactions of Reglan and Hyzaar, by gender? *:

female:

Anaemia (lack of blood)
Cardiovascular disorder (heart diseases)
Death
Insomnia (sleeplessness)
Platelet count decreased
Asthenia (weakness)
Chills (felling of cold)
Diabetes mellitus inadequate control
Haemorrhage (bleeding)
Pulmonary embolism (blockage of the main artery of the lung)

male:

Anxiety
Pain
Renal failure (kidney dysfunction)
Acute respiratory failure
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiomyopathy (weakening of the heart muscle)
Constipation
Coronary artery stenosis (narrowing of coronary artery)

What are the common drug interactions of Reglan and Hyzaar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Chest pain
Colonic polyp (extra part of colon tissue grow in intestine)
Diarrhoea
Dyspepsia (indigestion)
Eructation (release of gas from the digestive tract)
Faecal incontinence (a lack of control over passing stool)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Irritable bowel syndrome
Lipoma (a growth of fatty tissue that slowly develops just under your skin)

20-29:

n/a

30-39:

Anxiety
Arthralgia (joint pain)
Asthenia (weakness)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Hallucination (an experience involving the perception of something not present)
Mobility decreased (ability to move is reduced)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

40-49:

Cardiovascular disorder (heart diseases)
Chills (felling of cold)
Haemorrhage (bleeding)
Hypotension (abnormally low blood pressure)
Platelet count decreased
Renal failure (kidney dysfunction)
Swelling
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Anaemia (lack of blood)
Blood lactic acid increased

50-59:

Haematocrit decreased
Haemoglobin decreased
Hyperlipidaemia (presence of excess lipids in the blood)
Pain
Presyncope
Ventricular fibrillation (abnormally irregular heart rhythm)
Asthenia (weakness)
Acute respiratory failure
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

60+:

Weight decreased
Blood creatinine increased
Decreased appetite
Diarrhoea
Dry mouth
Dyspnoea (difficult or laboured respiration)
Gingivitis (inflammation of gums)
Pleural effusion (water on the lungs)
Swelling face
Urinary tract infection

What are the existing conditions these people have? *

Pain: 20 people, 25.97%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 18.18%
Depression: 11 people, 14.29%
High Blood Cholesterol: 11 people, 14.29%
Stress And Anxiety: 10 people, 12.99%
Neuralgia (pain in one or more nerves): 9 people, 11.69%
Fibromyalgia (a long-term condition which causes pain all over the body): 8 people, 10.39%
Cardiac Disorder: 8 people, 10.39%
Impaired Gastric Emptying: 8 people, 10.39%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 7 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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