Regular insulin and Fluoxetine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Regular insulin (insulin pork) and Fluoxetine (fluoxetine hydrochloride). Common drug interactions include aortic stenosis among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Regular insulin and Fluoxetine. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Regular insulin?

Regular insulin has active ingredients of insulin pork. It is often used in type 1 diabetes. eHealthMe is studying from 2,848 Regular insulin users. Check the latest studies of Regular insulin.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,824 Fluoxetine users. Check the latest studies of Fluoxetine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

22 people who take Regular insulin and Fluoxetine together, and have interactions are studied.

Regular insulin and Fluoxetine drug interactions.

What are the common drug interactions of Regular Insulin and Fluoxetine, by gender? *:

female:

Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrioventricular block (heart block)
Bipolar disorder (mood disorder)
Cardiac failure congestive
Cerebral infarction (less blood supply to brain resulting tissue damage)
Chest pain
Confusional state
Conjunctivitis (pink eye)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

male:

Anaemia (lack of blood)
Aphasia (damage to the parts of the brain that control language)
Injury
Palpitations (feelings or sensations that your heart is pounding or racing)
Restless legs syndrome (a powerful urge to move your legs)
Tardive dyskinesia (a disorder that involves involuntary movements)
Abdominal distension
Abdominal pain
Abdominal pain lower
Aggression

What are the common drug interactions of Regular Insulin and Fluoxetine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaemia (lack of blood)
Back pain
Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hypertension (high blood pressure)
Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

40-49:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Drug effect decreased
Hyperglycaemia (high blood sugar)
Vision blurred

50-59:

Accident
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrioventricular block (heart block)
Blood creatinine increased
Blood urea increased
Cardiac failure congestive
Conjunctivitis (pink eye)
Depersonalisation
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)

60+:

Febrile neutropenia (fever with reduced white blood cells)
Abdominal pain
Drug ineffective
Electrocardiogram qt prolonged
Failure to thrive (inadequate weight gain and physical growth in children)
Gastroenteritis (inflammation of stomach and intestine)
Hyperglycaemia (high blood sugar)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Neck pain
Palpitations (feelings or sensations that your heart is pounding or racing)

What are the existing conditions these people have? *

Diabetes: 5 people, 22.73%
High Blood Pressure: 3 people, 13.64%
Type 2 Diabetes: 2 people, 9.09%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 9.09%
High Blood Cholesterol: 2 people, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.09%
Bipolar Disorder (mood disorder): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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