Relafen and Centrum drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Relafen (nabumetone) and Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e). Common drug interactions include blood calcium increased among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Relafen and Centrum. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Relafen?

Relafen has active ingredients of nabumetone. It is often used in arthritis. eHealthMe is studying from 6,243 Relafen users. Check the latest studies of Relafen.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

On Aug, 05, 2026

81 people who take Relafen and Centrum together, and have interactions are studied.

What are the common drug interactions of Relafen and Centrum, by gender? *:

female:

Blood calcium increased
Calcium ionised increased
Dental caries
Haemoglobin decreased
Mouth ulceration (mouth ulcers)
Stomatitis (inflammation of mucous membrane of mouth)
Bone disorder
Dental fistula
Dermatitis allergic (inflammation of the skin due allergic reaction)
Oropharyngeal pain

male:

Arthralgia (joint pain)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Bone pain
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
Chest discomfort
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Contusion (a type of hematoma of tissue in which capillaries)

What are the common drug interactions of Relafen and Centrum, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anxiety
Asthenia (weakness)
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Back pain
Blood calcium increased
Bone disorder
Bone loss
Bone marrow oedema (inflammation that causes much than the needed fluid in a bone)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Calcium ionised increased

20-29:

n/a

30-39:

Headache (pain in head)
Parosmia (distortion of the sense of smell, as in smelling odours that are not present)

40-49:

Drug hypersensitivity
Headache (pain in head)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Weight increased

50-59:

Mouth ulceration (mouth ulcers)
Oropharyngeal plaque (hard deposit on oropharynx)
Periodontitis (inflammation of the tissue around the teeth)
Stomatitis (inflammation of mucous membrane of mouth)
Oropharyngeal pain
Back pain
Headache (pain in head)
Neck pain
Neuritis (inflammation of nerve)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)

60+:

Fall
Pneumonia
Asthenia (weakness)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Gingivitis (inflammation of gums)
Hypertension (high blood pressure)
Insomnia (sleeplessness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the existing conditions these people have? *

Pain: 21 people, 25.93%
Osteoporosis (bones weak and more likely to break): 18 people, 22.22%
High Blood Cholesterol: 16 people, 19.75%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 15 people, 18.52%
Osteopenia (a condition where bone mineral density is lower than normal): 13 people, 16.05%
Dyspnea (difficult or laboured breathing): 13 people, 16.05%
Arthropod Sting (arthropod bite): 13 people, 16.05%
High Blood Pressure: 7 people, 8.64%
Breast Cancer: 6 people, 7.41%
Asthma: 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

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