Relistor and Nuvigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Relistor (methylnaltrexone bromide) and Nuvigil (armodafinil). Common drug interactions include nausea among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Relistor and Nuvigil. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Relistor?

Relistor has active ingredients of methylnaltrexone bromide. eHealthMe is studying from 1,659 Relistor users. Check the latest studies of Relistor.

What is Nuvigil?

Nuvigil has active ingredients of armodafinil. It is often used in narcolepsy. eHealthMe is studying from 23,669 Nuvigil users. Check the latest studies of Nuvigil.

On Jul, 09, 2026

63 people who take Relistor and Nuvigil together, and have interactions are studied.

What are the common drug interactions of Relistor and Nuvigil, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Pneumonia
Pruritus (severe itching of the skin)
Seizure like phenomena (a variety of medical conditions may produce sudden episodes which have some similarities to epileptic seizures)
Snoring
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Surgery
Syncope (loss of consciousness with an inability to maintain postural tone)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Cystitis (inflammation of the wall of the bladder)

male:

Abdominal distension
Haematochezia (passage of stools containing blood)
Malaise (a feeling of general discomfort or uneasiness)
Pain
Proctalgia (pain in the rectum)
Rectal haemorrhage (bleeding from anus)
Sleep disorder
Swelling
Headache (pain in head)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)

What are the common drug interactions of Relistor and Nuvigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Juvenile myoclonic epilepsy (childhood epilepsy occurring early in morning affecting 12 to 18 years)
Loss of consciousness
Heart rate increased
Hospitalisation
Cardiac arrest
Blood pressure increased
Drug hypersensitivity
Seizure like phenomena (a variety of medical conditions may produce sudden episodes which have some similarities to epileptic seizures)
Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

Facial bones fracture (bone fracture of face)
Fall
Pneumonia

50-59:

Exostosis (formation of new bone on the surface of a bone)
Feeling jittery
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Irritability
Micturition urgency (urgency to pass the urine)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Surgery

60+:

Cystitis (inflammation of the wall of the bladder)
Fall
Diarrhoea
Gastrointestinal infection (infection of stomach and intestine)
Hypersensitivity
Knee arthroplasty
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Fungal infection
Muscle spasms (muscle contraction)
Tooth fracture

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 49 people, 77.78%
Constipation: 5 people, 7.94%

* Approximation only. Some reports may have incomplete information.

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