Remodulin and Sinemet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Remodulin (treprostinil sodium) and Sinemet (carbidopa; levodopa). Common drug interactions include syncope among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Remodulin and Sinemet. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Remodulin?

Remodulin has active ingredients of treprostinil sodium. It is often used in primary pulmonary hypertension. eHealthMe is studying from 55,843 Remodulin users. Check the latest studies of Remodulin.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

15 people who take Remodulin and Sinemet together, and have interactions are studied.

Remodulin and Sinemet drug interactions.

What are the common drug interactions of Remodulin and Sinemet, by gender? *:

female:

Syncope (loss of consciousness with an inability to maintain postural tone)
Acute respiratory failure
Cellulitis (infection under the skin)
Fluid overload (too much fluid in the blood)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pleural effusion (water on the lungs)
Ear haemorrhage (bleeding from ear)
Localised oedema (fluid retention in a particular part of the body)
Muscle spasms (muscle contraction)

male:

Death
Fall
Haemorrhage intracranial (bleeding within the skull)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Remodulin and Sinemet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cellulitis (infection under the skin)
Fluid overload (too much fluid in the blood)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pleural effusion (water on the lungs)
Ear haemorrhage (bleeding from ear)
Localised oedema (fluid retention in a particular part of the body)
Muscle spasms (muscle contraction)
Otorrhoea (discharge from the ear)
Device occlusion

50-59:

n/a

60+:

Death
Device related infection

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 13 people, 86.67%
Oedema (fluid collection in tissue): 4 people, 26.67%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 6.67%
Headache (pain in head): 1 person, 6.67%
Cardiac Failure: 1 person, 6.67%
Constipation: 1 person, 6.67%
Drug Hypersensitivity: 1 person, 6.67%
Gastric Ulcer (stomach ulcer): 1 person, 6.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.67%
Joint Pain: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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