Renagel and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Renagel (sevelamer hydrochloride) and Diphen (diphenhydramine hydrochloride). Common drug interactions include atrial fibrillation among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Renagel and Diphen. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Renagel?

Renagel has active ingredients of sevelamer hydrochloride. eHealthMe is studying from 8,246 Renagel users. Check the latest studies of Renagel.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

On Jul, 13, 2026

65 people who take Renagel and Diphen together, and have interactions are studied.

What are the common drug interactions of Renagel and Diphen, by gender? *:

female:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Diarrhoea
Renal failure chronic (long lasting kidney dysfunction)
Emotional distress
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain in extremity
Pruritus (severe itching of the skin)
Abdominal pain
Anaemia (lack of blood)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

male:

Renal failure (kidney dysfunction)
Hypotension (abnormally low blood pressure)
Gastroenteritis (inflammation of stomach and intestine)
Anaemia (lack of blood)
Bradycardia (abnormally slow heart action)
Dyspnoea (difficult or laboured respiration)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Leukocytosis (increased white blood cells)
Metaplasia (change in the type of adult cells in a tissue to a form abnormal for that tissue)
Mobility decreased (ability to move is reduced)

What are the common drug interactions of Renagel and Diphen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Cardiac arrest
Arteriovenous fistula occlusion
Diarrhoea
Focal segmental glomerulosclerosis (scar tissue that forms in parts of the kidney called glomeruli)
Gastroenteritis (inflammation of stomach and intestine)
Hypotension (abnormally low blood pressure)
Renal failure (kidney dysfunction)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Metaplasia (change in the type of adult cells in a tissue to a form abnormal for that tissue)

20-29:

n/a

30-39:

Chronic kidney disease
Renal failure (kidney dysfunction)
Anoxia (low oxygen)
Apnoea (suspension of external breathing)
Epistaxis (bleed from the nose)
Haemoglobin decreased
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypotension (abnormally low blood pressure)
Lymphoma (cancer that begins in immune system cells)
Lymphoproliferative disorder (a medical condition in which the immune system makes too many white blood cells)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Renal failure (kidney dysfunction)
Tooth loss
Bone density decreased
Osteomyelitis (infection of bone)
Rotator cuff repair
Anaphylactic reaction (serious allergic reaction)

50-59:

Atelectasis (partial or complete collapse of the lung)
Bacterial test positive
Blood alkaline phosphatase increased
Blood creatinine increased
Blood glucose increased
Blood pressure decreased
Cardiac arrest
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiomegaly (increased size of heart than normal)
Chest pain

60+:

Anxiety
Dyspnoea (difficult or laboured respiration)
Injury
Pain
Skin discolouration (change of skin colour)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Hypotension (abnormally low blood pressure)
Leukocytosis (increased white blood cells)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

What are the existing conditions these people have? *

Constipation: 11 people, 16.92%
High Blood Pressure: 10 people, 15.38%
Pain: 8 people, 12.31%
Nausea (feeling of having an urge to vomit): 8 people, 12.31%
Joint Pain: 8 people, 12.31%
Catheter Related Complication: 8 people, 12.31%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 10.77%
Anaemia (lack of blood): 6 people, 9.23%
Indigestion: 6 people, 9.23%
Cough: 5 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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