Renvela and Medrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Renvela (sevelamer carbonate) and Medrol (methylprednisolone). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Renvela and Medrol. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Renvela?

Renvela has active ingredients of sevelamer carbonate. eHealthMe is studying from 10,923 Renvela users. Check the latest studies of Renvela.

What is Medrol?

Medrol has active ingredients of methylprednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 24,443 Medrol users. Check the latest studies of Medrol.

On Jul, 20, 2026

35 people who take Renvela and Medrol together, and have interactions are studied.

What are the common drug interactions of Renvela and Medrol, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Nephrogenic anaemia (anaemia due to kidney disease)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypervolaemia (abnormally increased volume of blood)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Drug hypersensitivity
Respiratory distress (difficulty in breathing)
Acute hepatic failure
Asthenia (weakness)

male:

Chronic kidney disease
Hospitalisation
Pain
Myeloid leukaemia (a type of cancer in which the bone marrow makes abnormal myeloblasts)
Nephrogenic anaemia (anaemia due to kidney disease)
Nephropathy (damage to or disease of a kidney)
Acute myocardial infarction (acute heart attack)
Apathy
Asthenia (weakness)
Cachexia (loss of weight)

What are the common drug interactions of Renvela and Medrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hospitalisation
Hypertension (high blood pressure)
Urinary tract infection
Infection
Chronic kidney disease
Death

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Emotional distress
Pain
Myeloid leukaemia (a type of cancer in which the bone marrow makes abnormal myeloblasts)
Anaemia (lack of blood)
Apathy
Asthenia (weakness)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Nephrogenic anaemia (anaemia due to kidney disease)
Arrhythmia (irregular heartbeat)
Atrioventricular block (heart block)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic nephropathy (diabetic kidney disease)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypervolaemia (abnormally increased volume of blood)

60+:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Hypoaesthesia (reduced sense of touch or sensation)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Lactic acidosis (low ph in body tissues)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Blood pressure increased
Feeling hot
Nephropathy (damage to or disease of a kidney)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 28.57%
Pain: 9 people, 25.71%
High Blood Pressure: 9 people, 25.71%
High Blood Cholesterol: 7 people, 20.00%
Indigestion: 5 people, 14.29%
Infection: 4 people, 11.43%
Hypersensitivity: 3 people, 8.57%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 3 people, 8.57%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 8.57%
Multiple Myeloma (cancer of the plasma cells): 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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