Repaglinide and Lamotrigine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Repaglinide (repaglinide) and Lamotrigine (lamotrigine). Common drug interactions include bundle branch block left among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Repaglinide and Lamotrigine. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Repaglinide?

Repaglinide has active ingredients of repaglinide. It is often used in diabetes. eHealthMe is studying from 8,226 Repaglinide users. Check the latest studies of Repaglinide.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

17 people who take Repaglinide and Lamotrigine together, and have interactions are studied.

Repaglinide and Lamotrigine drug interactions.

What are the common drug interactions of Repaglinide and Lamotrigine, by gender? *:

female:

Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Suicide attempt
Electrocardiogram qrs complex prolonged
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Discomfort
Rash
Sleep disorder
Loss of consciousness
Stupor (lack of critical cognitive function and level of consciousness)
Cardiotoxicity (damage to the heart muscle)

male:

Constipation
Adverse event
Muscle twitching
Night sweats (sweating in night)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Restlessness (not able to rest)
Thirst
Upper limb fracture
Abdominal discomfort
Arthralgia (joint pain)

What are the common drug interactions of Repaglinide and Lamotrigine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Discomfort
Rash
Sleep disorder
Pruritus (severe itching of the skin)
Scab (a hard coating on the skin formed during the wound healing)
Skin swelling

40-49:

Grand mal convulsion (a type of generalized seizure that affects the entire brain)

50-59:

Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Suicide attempt
Electrocardiogram qrs complex prolonged
Loss of consciousness
Stupor (lack of critical cognitive function and level of consciousness)
Cardiotoxicity (damage to the heart muscle)
Unresponsive to stimuli
Abdominal discomfort
Arthralgia (joint pain)
Back pain

60+:

Atrioventricular block (heart block)
Bradycardia (abnormally slow heart action)
Skin lesion
Thrombocytopenia (decrease of platelets in blood)
Thrombosis (formation of a blood clot inside a blood vessel)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diarrhoea haemorrhagic (bloody diarrhoea)
Electrocardiogram qt prolonged
Hyperglycaemia (high blood sugar)
Hyperkalaemia (damage to or disease of the kidney)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 11.76%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 2 people, 11.76%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 5.88%
Type 2 Diabetes: 1 person, 5.88%
Suicide Attempt: 1 person, 5.88%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.88%
Schizoaffective Disorder Depressive Type (mental illness featuring schizophrenia and a mood disorder): 1 person, 5.88%
Parkinson's Disease: 1 person, 5.88%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 1 person, 5.88%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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