Repaglinide and Xeloda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Repaglinide (repaglinide) and Xeloda (capecitabine). Common drug interactions include asthenia among females and adenocarcinoma pancreas among males.

The phase IV clinical study analyzes what interactions people have when they take Repaglinide and Xeloda. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Repaglinide?

Repaglinide has active ingredients of repaglinide. It is often used in diabetes. eHealthMe is studying from 8,226 Repaglinide users. Check the latest studies of Repaglinide.

What is Xeloda?

Xeloda has active ingredients of capecitabine. It is often used in colon cancer. eHealthMe is studying from 46,649 Xeloda users. Check the latest studies of Xeloda.



On Jul, 10, 2026

14 people who take Repaglinide and Xeloda together, and have interactions are studied.

Repaglinide and Xeloda drug interactions.

What are the common drug interactions of Repaglinide and Xeloda, by gender? *:

female:

  1. Asthenia (weakness)
  2. Dyspnoea (difficult or laboured respiration)
  3. Escherichia urinary tract infection (urinary tract infection by escherichia coli)
  4. Osteonecrosis of jaw (death of bone of jaw)
  5. Sepsis (a severe blood infection that can lead to organ failure and death)
  6. Bone loss
  7. Cardiomegaly (increased size of heart than normal)
  8. Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
  9. Emotional distress
  10. Fall

male:

  1. Adenocarcinoma pancreas (cancer of pancreas)
  2. Bacterial sepsis
  3. Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
  4. Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
  5. Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
  6. Bone marrow failure
  7. Cardiomyopathy (weakening of the heart muscle)
  8. Encephalopathy (functioning of the brain is affected by some agent or condition)
  9. Interstitial lung disease
  10. Mucosal inflammation (infection of mucous membrane)

What are the common drug interactions of Repaglinide and Xeloda, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Asthenia (weakness)
  2. Dyspnoea (difficult or laboured respiration)
  3. Escherichia urinary tract infection (urinary tract infection by escherichia coli)
  4. Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

n/a

60+:

  1. Osteonecrosis of jaw (death of bone of jaw)
  2. Bone loss
  3. Loose tooth
  4. Metastases to neck (cancer spreads to neck)
  5. Nephrolithiasis (calculi in the kidneys)
  6. Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
  7. Ovarian cyst (fluid filled sac of the ovary)
  8. Periarthritis (inflammation of the external coats of an artery and of the tissues around the artery)
  9. Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
  10. Quality of life decreased

What are the existing conditions these people have? *

  1. Pancreatic Neuroendocrine Tumor Metastatic: 3 people, 21.43%
  2. Pain: 2 people, 14.29%
  3. Metastases To Bone (cancer spreads to bone): 2 people, 14.29%
  4. Rectal Neoplasm (tumour of rectum): 1 person, 7.14%
  5. Rectal Cancer Metastatic (cancer of rectum spreads to other): 1 person, 7.14%
  6. Gastrointestinal Neoplasm (cancer tumour of digestive tract): 1 person, 7.14%
  7. Breast Cancer Metastatic: 1 person, 7.14%
  8. Adenocarcinoma Pancreas (cancer of pancreas): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Repaglinide and Xeloda:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Repaglinide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Xeloda:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Repaglinide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Xeloda and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on repaglinide and capecitabine (the active ingredients of Repaglinide and Xeloda, respectively), and Repaglinide and Xeloda (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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