Repatha and Aleve drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Repatha (evolocumab) and Aleve (naproxen sodium). Common drug interactions include local swelling among females and injection site pain among males.

The phase IV clinical study analyzes what interactions people have when they take Repatha and Aleve. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,258 Repatha users. Check the latest studies of Repatha.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

On Aug, 12, 2026

47 people who take Repatha and Aleve together, and have interactions are studied.

What are the common drug interactions of Repatha and Aleve, by gender? *:

female:

Local swelling (swelling at the site of some application of substance or injury)
Mobility decreased (ability to move is reduced)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nasopharyngitis (inflammation of the nasopharynx)
Nervousness
Oropharyngeal pain
Physical product label issue
Rash pruritic (redness with itching)
Pain in extremity

male:

Injection site pain
Arrhythmia (irregular heartbeat)
Electrocardiogram qt prolonged
Fatigue (feeling of tiredness)
Hepatic enzyme increased
Influenza like illness
Migraine (headache)
Myalgia (muscle pain)
Nasopharyngitis (inflammation of the nasopharynx)
Neutropenia (an abnormally low number of neutrophils)

What are the common drug interactions of Repatha and Aleve, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Carotid bruit (sound heard over the carotid artery area during auscultation)
Cerebrovascular stenosis (narrowing of brain blood vessels)
Malaise (a feeling of general discomfort or uneasiness)
Thrombocytopenia (decrease of platelets in blood)
Vitamin d deficiency
Nausea (feeling of having an urge to vomit)
Depression
Fatigue (feeling of tiredness)
Injection site haemorrhage (bleeding from injection site)
Injection site pain

60+:

Arthralgia (joint pain)
Pain in extremity
Visual impairment
Injection site pain
Pruritus (severe itching of the skin)
Crying
Influenza like illness
Fatigue (feeling of tiredness)
Injection site pruritus (severe itching at injection site)
Anxiety

What are the existing conditions these people have? *

Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 10.64%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

Do you take Repatha and Aleve?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously