Repatha and Contrave drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Repatha (evolocumab) and Contrave (bupropion hydrochloride; naltrexone hydrochloride). Common drug interactions include alopecia among females.

The phase IV clinical study analyzes what interactions people have when they take Repatha and Contrave. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,258 Repatha users. Check the latest studies of Repatha.

What is Contrave?

Contrave has active ingredients of bupropion hydrochloride; naltrexone hydrochloride. It is often used in weight loss. eHealthMe is studying from 5,553 Contrave users. Check the latest studies of Contrave.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

12 people who take Repatha and Contrave together, and have interactions are studied.

What are the common drug interactions of Repatha and Contrave, by gender? *:

female:

Alopecia (absence of hair from areas of the body)
Constipation
Tinnitus (a ringing in the ears)
Weight fluctuation
Nerve compression
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Osteoporosis (bones weak and more likely to break)
Faecaloma (hard mass of fecal matter)
Nasopharyngitis (inflammation of the nasopharynx)
Wheezing (a high-pitched whistling sound made while you breath)

male:

n/a

What are the common drug interactions of Repatha and Contrave, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Chest pain
Heart rate increased

60+:

Alopecia (absence of hair from areas of the body)
Constipation
Muscle injury
Nasopharyngitis (inflammation of the nasopharynx)
Nerve compression
Osteoporosis (bones weak and more likely to break)
Procedural pain
Tinnitus (a ringing in the ears)
Weight fluctuation
Wheezing (a high-pitched whistling sound made while you breath)

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 11 people, 91.67%
High Blood Pressure: 11 people, 91.67%
Blood Pressure Abnormal: 11 people, 91.67%
Pain: 9 people, 75.00%
Neuralgia (pain in one or more nerves): 9 people, 75.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 75.00%
Spinal Pain (pain in spine): 7 people, 58.33%
Macular Degeneration (painless eye condition that leads to the gradual loss of central vision): 7 people, 58.33%
Stress And Anxiety: 2 people, 16.67%
Sleep Disorder: 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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