Repatha and Lamotrigine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Repatha (evolocumab) and Lamotrigine (lamotrigine). Common drug interactions include amnesia among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Repatha and Lamotrigine. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,258 Repatha users. Check the latest studies of Repatha.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

29 people who take Repatha and Lamotrigine together, and have interactions are studied.

Repatha and Lamotrigine drug interactions.

What are the common drug interactions of Repatha and Lamotrigine, by gender? *:

female:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Aphasia (damage to the parts of the brain that control language)
Blindness
Blood calcium increased
Fatigue (feeling of tiredness)
Migraine (headache)
Heart rate decreased
Arrhythmia (irregular heartbeat)
Brain injury
Colitis ulcerative (inflammation of colon with ulcer)

male:

Death
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Injection site swelling
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness postural
Drug ineffective
Fatigue (feeling of tiredness)
Hypersomnia (excessive daytime sleepiness (eds))
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)

What are the common drug interactions of Repatha and Lamotrigine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Death
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

50-59:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Aphasia (damage to the parts of the brain that control language)
Blindness
Blood calcium increased
Fatigue (feeling of tiredness)
Migraine (headache)
Flushing (the warm, red condition of human skin)
Pruritus (severe itching of the skin)
Rash
Skin burning sensation

60+:

Death
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Eye pruritus (eye itching)
Eye swelling
Fatigue (feeling of tiredness)
Frequent bowel movements
Gastric disorder (disease of stomach)
Hallucination, visual (seeing things that aren't there)
Hospitalisation
Hypersomnia (excessive daytime sleepiness (eds))

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 17.24%
High Blood Pressure: 5 people, 17.24%
Atherosclerosis (disorder of the arteries): 4 people, 13.79%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 10.34%
Depression: 3 people, 10.34%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 6.90%
Heart Disease: 2 people, 6.90%
Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 2 people, 6.90%
Gastric Ph Decreased: 2 people, 6.90%
Fungal Infection: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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