Repatha and Lescol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Repatha (evolocumab) and Lescol (fluvastatin sodium). Common drug interactions include drug ineffective among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Repatha and Lescol. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,256 Repatha users. Check the latest studies of Repatha.

What is Lescol?

Lescol has active ingredients of fluvastatin sodium. It is often used in high blood cholesterol. eHealthMe is studying from 7,306 Lescol users. Check the latest studies of Lescol.

On Jul, 07, 2026

63 people who take Repatha and Lescol together, and have interactions are studied.

What are the common drug interactions of Repatha and Lescol, by gender? *:

female:

Drug ineffective
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Insomnia (sleeplessness)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Asthenia (weakness)
Cardiovascular disorder (heart diseases)
Nausea (feeling of having an urge to vomit)

male:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug ineffective
Food allergy
Headache (pain in head)
Multimorbidity (co-occurrence of two or more chronic medical conditions in one person)
Respiratory distress (difficulty in breathing)
Somnolence (a state of near-sleep, a strong desire for sleep)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Cardiac disorder

What are the common drug interactions of Repatha and Lescol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug ineffective
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

20-29:

Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug ineffective
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Multimorbidity (co-occurrence of two or more chronic medical conditions in one person)

30-39:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug ineffective
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Cardiac disorder
Low density lipoprotein increased (cholesterol increased in blood)
Multimorbidity (co-occurrence of two or more chronic medical conditions in one person)

40-49:

Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Adverse drug reaction
Drug ineffective
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

50-59:

Arthralgia (joint pain)
Headache (pain in head)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Cardiovascular disorder (heart diseases)
Drug ineffective
Acute myocardial infarction (acute heart attack)
Attention deficit/hyperactivity disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)

60+:

Asthenia (weakness)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Oral discomfort (pain or irritation in mouth)
Palpitations (feelings or sensations that your heart is pounding or racing)
Back pain
Blood glucose increased
Hypotension (abnormally low blood pressure)
Influenza like illness
Insomnia (sleeplessness)

What are the existing conditions these people have? *

Low Density Lipoprotein: 36 people, 57.14%
Low Density Lipoprotein Abnormal (cholesterol abnormal): 14 people, 22.22%

* Approximation only. Some reports may have incomplete information.

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