Repatha and Phenergan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Repatha (evolocumab) and Phenergan (promethazine hydrochloride). Common drug interactions include back pain among females and sciatica among males.

The phase IV clinical study analyzes what interactions people have when they take Repatha and Phenergan. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,258 Repatha users. Check the latest studies of Repatha.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

11 people who take Repatha and Phenergan together, and have interactions are studied.

Repatha and Phenergan drug interactions.

What are the common drug interactions of Repatha and Phenergan, by gender? *:

female:

Back pain
Urticaria (rash of round, red welts on the skin that itch intensely)
Arthralgia (joint pain)
Chills (felling of cold)
Dizziness
Dyspnoea (difficult or laboured respiration)
Influenza like illness
Sleep disorder due to general medical condition, insomnia type (a conditions that prevent a person from getting restful sleep due to mental condition of not getting sleep)
Upper respiratory tract infection
Haematocrit decreased

male:

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)

What are the common drug interactions of Repatha and Phenergan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Back pain
Dizziness
Fatigue (feeling of tiredness)
Influenza like illness
Pain
Sleep disorder due to general medical condition, insomnia type (a conditions that prevent a person from getting restful sleep due to mental condition of not getting sleep)
Upper respiratory tract infection
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Chest pain
Dyspnoea (difficult or laboured respiration)

60+:

Pain in extremity
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Fatigue (feeling of tiredness)
Haematocrit decreased
Haemoglobin decreased
Injection site haematoma (localized swelling filled with blood at injection site)
Injection site swelling
Muscle spasms (muscle contraction)
Oesophageal spasm (contraction of oesophagus)
Pain in jaw

What are the existing conditions these people have? *

Pain: 3 people, 27.27%
Impaired Gastric Emptying: 3 people, 27.27%
Muscle Spasms (muscle contraction): 3 people, 27.27%
Nausea And Vomiting: 3 people, 27.27%
Chest Pain: 2 people, 18.18%
Migraine (headache): 2 people, 18.18%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 2 people, 18.18%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 18.18%
Thyroid Diseases: 2 people, 18.18%
Idiopathic Urticaria (allergic reactions, presence of hives with unknown cause): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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