Repatha and Requip drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Repatha (evolocumab) and Requip (ropinirole hydrochloride). Common drug interactions include anaphylactic shock among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Repatha and Requip. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,256 Repatha users. Check the latest studies of Repatha.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

On Jul, 10, 2026

16 people who take Repatha and Requip together, and have interactions are studied.

What are the common drug interactions of Repatha and Requip, by gender? *:

female:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Chest pain
Dyspnoea (difficult or laboured respiration)
Asthenia (weakness)
Blood creatinine increased
Blood pressure increased
Death
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Epistaxis (bleed from the nose)
Fluid retention (an abnormal accumulation of fluid in the blood)

male:

Weight increased
Back pain
Death
Dry mouth
Headache (pain in head)
Influenza like illness
Myalgia (muscle pain)
Rhinorrhoea (watery mucus discharge from the nose)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Stent placement

What are the common drug interactions of Repatha and Requip, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Chest pain
Dyspnoea (difficult or laboured respiration)
Death
Joint swelling
Peripheral swelling
Swelling

60+:

Headache (pain in head)
Weight increased
Muscle spasms (muscle contraction)
Myalgia (muscle pain)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain in extremity
Rhinorrhoea (watery mucus discharge from the nose)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Stent placement
Tendon disorder (disease of tendon)

What are the existing conditions these people have? *

Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 25.00%
Stress And Anxiety: 2 people, 12.50%
Pain: 2 people, 12.50%
Muscle Spasms (muscle contraction): 2 people, 12.50%
Dyslipidaemia (abnormal amount of lipids): 2 people, 12.50%
Blood Pressure Abnormal: 2 people, 12.50%
Urinary Tract Infection: 1 person, 6.25%
Thrombosis (formation of a blood clot inside a blood vessel): 1 person, 6.25%
Heart Rate Increased: 1 person, 6.25%
Cushing's Syndrome (obesity, a rounded face, increased fat): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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