Samsca and Repatha drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Samsca (tolvaptan) and Repatha (evolocumab). Common drug interactions include dermatitis allergic among females and gastrointestinal perforation among males.

The phase IV clinical study analyzes what interactions people have when they take Samsca and Repatha. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Samsca?

Samsca has active ingredients of tolvaptan. eHealthMe is studying from 8,139 Samsca users. Check the latest studies of Samsca.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,228 Repatha users. Check the latest studies of Repatha.

On Oct, 26, 2025

11 people who take Samsca and Repatha together, and have interactions are studied.

What are the common drug interactions of Samsca and Repatha, by gender? *:

female:

Dermatitis allergic (inflammation of the skin due allergic reaction)
Injection site infection
Injection site reaction
Altered state of consciousness (altered state of mind)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Decreased appetite
Diarrhoea
Dizziness
Epistaxis (bleed from the nose)
Gastroenteritis (inflammation of stomach and intestine)

male:

Gastrointestinal perforation (hole in the digestive tract)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Cardiac failure
Blood pressure systolic increased
Septic shock (shock due to blood infection)
Blood creatine increased
Blood potassium increased
Cellulitis (infection under the skin)
Endocarditis (inflammation in heart muscle)

What are the common drug interactions of Samsca and Repatha, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood potassium increased
Cardiac failure
Blood pressure systolic increased
Blood creatine increased

50-59:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Cellulitis (infection under the skin)

60+:

Gastrointestinal perforation (hole in the digestive tract)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Endocarditis (inflammation in heart muscle)

What are the existing conditions these people have? *

Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 27.27%
Nephrotic Syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema): 2 people, 18.18%
Low Density Lipoprotein Increased (cholesterol increased in blood): 2 people, 18.18%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 2 people, 18.18%
High Blood Pressure: 2 people, 18.18%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 18.18%
Zinc Deficiency: 1 person, 9.09%
Folate Deficiency (lack of folic acid): 1 person, 9.09%
Amyloidosis (a tumour within which amyloid is produced): 1 person, 9.09%
Anaemia (lack of blood): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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