Repatha and Xywav drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Repatha (evolocumab) and Xywav (calcium oxybate; magnesium oxybate; potassium oxybate; sodium oxybate). Common drug interactions include alanine aminotransferase increased among females and blood pressure increased among males.

The phase IV clinical study analyzes what interactions people have when they take Repatha and Xywav. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,256 Repatha users. Check the latest studies of Repatha.

What is Xywav?

Xywav has active ingredients of calcium oxybate; magnesium oxybate; potassium oxybate; sodium oxybate. eHealthMe is studying from 7,134 Xywav users. Check the latest studies of Xywav.

On Jul, 27, 2026

20 people who take Repatha and Xywav together, and have interactions are studied.

What are the common drug interactions of Repatha and Xywav, by gender? *:

female:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood creatinine increased
Blood pressure decreased
Blood urea increased
Cardiovascular disorder (heart diseases)
Hangover
Headache (pain in head)
Muscle spasms (muscle contraction)

male:

Blood pressure increased
Gait disturbance
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Visual impairment
Headache (pain in head)
Upper-airway cough syndrome
Urinary tract infection
Diarrhoea
Disturbance in attention
Drug intolerance (drug sensitivity)

What are the common drug interactions of Repatha and Xywav, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Diarrhoea
Disturbance in attention
Somnolence (a state of near-sleep, a strong desire for sleep)
Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation)
Urticaria (rash of round, red welts on the skin that itch intensely)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Pain
Post procedural infection
Tenderness (pain or discomfort when an affected area is touched)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 70.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 55.00%
Drowsiness: 10 people, 50.00%
Pain: 3 people, 15.00%
Insomnia (sleeplessness): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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