Requip and Droxidopa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Requip (ropinirole hydrochloride) and Droxidopa (droxidopa). Common drug interactions include delirium among females and sudden onset of sleep among males.

The phase IV clinical study analyzes what interactions people have when they take Requip and Droxidopa. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

What is Droxidopa?

Droxidopa has active ingredients of droxidopa. eHealthMe is studying from 1,093 Droxidopa users. Check the latest studies of Droxidopa.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

22 people who take Requip and Droxidopa together, and have interactions are studied.

What are the common drug interactions of Requip and Droxidopa, by gender? *:

female:

Delirium (wild excitement)
Delusion (a false belief or opinion)
Palpitations (feelings or sensations that your heart is pounding or racing)
Decreased appetite
Depressed level of consciousness
Hallucination (an experience involving the perception of something not present)
Negativism (negative thoughts)
Somnolence (a state of near-sleep, a strong desire for sleep)
Sudden onset of sleep
Abdominal discomfort

male:

Sudden onset of sleep
Hallucination (an experience involving the perception of something not present)
Dehydration (dryness resulting from the removal of water)
Allodynia (a condition in which pain is caused by a stimulus that does not normally elicit pain)
Cellulitis (infection under the skin)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral swelling
Somnolence (a state of near-sleep, a strong desire for sleep)
Death
Back disorder

What are the common drug interactions of Requip and Droxidopa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Decreased appetite

30-39:

n/a

40-49:

Aggression
Communication disorder (speech and language disorder)
Dehydration (dryness resulting from the removal of water)
Delusion (a false belief or opinion)
Decreased appetite

50-59:

Cold sweat
Pallor
Respiratory depression (respiration has a rate below 12 breaths)
Somnolence (a state of near-sleep, a strong desire for sleep)
Urticaria (rash of round, red welts on the skin that itch intensely)

60+:

Hallucination (an experience involving the perception of something not present)
Pyrexia (fever)
Death
Decreased appetite
Abdominal discomfort
Asthenia (weakness)
Back disorder
Blood glucose increased
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)

What are the existing conditions these people have? *

Parkinson's Disease: 17 people, 77.27%
Type 2 Diabetes: 2 people, 9.09%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 2 people, 9.09%
Insomnia (sleeplessness): 2 people, 9.09%
Hypotension (abnormally low blood pressure): 2 people, 9.09%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 9.09%
Dementia With Lewy Bodies (progressive degenerative disease or syndrome of the brain): 2 people, 9.09%
Delusion (a false belief or opinion): 2 people, 9.09%
Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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