Requip and Enablex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Requip (ropinirole hydrochloride) and Enablex (darifenacin hydrobromide). Common drug interactions include cardio-respiratory arrest among females and multiple sclerosis relapse among males.

The phase IV clinical study analyzes what interactions people have when they take Requip and Enablex. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

What is Enablex?

Enablex has active ingredients of darifenacin hydrobromide. It is often used in urge incontinence. eHealthMe is studying from 4,934 Enablex users. Check the latest studies of Enablex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

53 people who take Requip and Enablex together, and have interactions are studied.

What are the common drug interactions of Requip and Enablex, by gender? *:

female:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cellulitis (infection under the skin)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dysphagia (a condition in which swallowing is difficult or painful)
Gastric disorder (disease of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
General physical health deterioration (weak health status)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)

male:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Fall
Hip fracture
Impaired driving ability
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Urinary retention (the inability to completely or partially empty the bladder)
Urinary tract infection
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

What are the common drug interactions of Requip and Enablex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abortion spontaneous (naturally occurring miscarriage)

40-49:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Back pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Dependence
Drug abuse
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Eating disorder
Fall

50-59:

Immune reconstitution syndrome (immune recovery syndrome)
Confusional state
Alanine aminotransferase increased
Alopecia (absence of hair from areas of the body)
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Cellulitis (infection under the skin)
Chest pain
Decreased appetite
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

60+:

Haematuria (presence of blood in urine)
Dizziness
Myalgia (muscle pain)
Oedema peripheral (superficial swelling)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Renal failure (kidney dysfunction)
Bone disorder
Bone marrow failure
Cardiac failure congestive

What are the existing conditions these people have? *

Pain: 15 people, 28.30%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 14 people, 26.42%
High Blood Pressure: 9 people, 16.98%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 8 people, 15.09%
Urinary Tract Infection: 7 people, 13.21%
Depression: 7 people, 13.21%
Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 13.21%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 13.21%
Hypertriglyceridaemia (excess of triglycerides in the blood): 7 people, 13.21%
Mixed Incontinence (a combination of stress and urge incontinence): 7 people, 13.21%

* Approximation only. Some reports may have incomplete information.

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