Requip and Hydroxyzine hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Requip (ropinirole hydrochloride) and Hydroxyzine hydrochloride (hydroxyzine hydrochloride). Common drug interactions include dry eye among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Requip and Hydroxyzine hydrochloride. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

What is Hydroxyzine hydrochloride?

Hydroxyzine hydrochloride has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 10,486 Hydroxyzine hydrochloride users. Check the latest studies of Hydroxyzine hydrochloride.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

56 people who take Requip and Hydroxyzine hydrochloride together, and have interactions are studied.

Requip and Hydroxyzine hydrochloride drug interactions.

What are the common drug interactions of Requip and Hydroxyzine Hydrochloride, by gender? *:

female:

Dry eye (lack of adequate tears)
Aphonia (inability to produce voice)
Blood pressure increased
Contusion (a type of hematoma of tissue in which capillaries)
Decreased appetite
Drug ineffective
Palpitations (feelings or sensations that your heart is pounding or racing)
Age-related macular degeneration
Arthralgia (joint pain)
Ascites (accumulation of fluid in the abdominal cavity)

male:

Pneumonia
Hypotension (abnormally low blood pressure)
Respiratory failure (inadequate gas exchange by the respiratory system)
Rib fracture
Salivary hypersecretion (excess saliva secretion)
Sleep-related eating disorder (abnormal eating patterns during the night)
Somnolence (a state of near-sleep, a strong desire for sleep)
Vocal cord paralysis
Weight decreased
Asthenia (weakness)

What are the common drug interactions of Requip and Hydroxyzine Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Fatigue (feeling of tiredness)
Headache (pain in head)
Migraine (headache)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Sinusitis (inflammation of sinus)
Toothache (tooth pain)
Upper respiratory tract infection

30-39:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Increased upper airway secretion
Laryngeal disorder (disease of larynx related to voice)
Oral candidiasis (fungal infection of mouth)
Pneumonia
Post procedural complication
Respiratory failure (inadequate gas exchange by the respiratory system)
Rib fracture
Sleep-related eating disorder (abnormal eating patterns during the night)

40-49:

Dry eye (lack of adequate tears)
Age-related macular degeneration
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Discomfort
Dizziness
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Pain in extremity
Schizophrenia, undifferentiated type (a type characterized by the presence of prominent psychotic symptoms but not classifiable as catatonic, disorganized, or paranoid)
Syncope (loss of consciousness with an inability to maintain postural tone)
Vulvovaginal candidiasis (vulvovaginal infection by fungi)

50-59:

Fall
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Groin pain
Headache (pain in head)
Hyperkalaemia (damage to or disease of the kidney)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypersomnia (excessive daytime sleepiness (eds))
Hypertension (high blood pressure)

60+:

Hypotension (abnormally low blood pressure)
Diarrhoea
Abdominal pain
Blood creatine increased
Blood pressure increased
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Feeling of body temperature change
Heart rate decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 28.57%
Immunodeficiency Common Variable: 10 people, 17.86%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 17.86%
High Blood Pressure: 7 people, 12.50%
Pain: 6 people, 10.71%
Drowsiness: 6 people, 10.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 10.71%
Nausea (feeling of having an urge to vomit): 5 people, 8.93%
Primary Immunodeficiency Syndrome: 5 people, 8.93%
Sleep Disorder: 5 people, 8.93%

* Approximation only. Some reports may have incomplete information.

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