Requip and Progesterone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Requip (ropinirole hydrochloride) and Progesterone (progesterone). Common drug interactions include influenza like illness among females and adverse drug reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Requip and Progesterone. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

What is Progesterone?

Progesterone has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 21,021 Progesterone users. Check the latest studies of Progesterone.



On Jul, 26, 2026

58 people who take Requip and Progesterone together, and have interactions are studied.

Requip and Progesterone drug interactions.

What are the common drug interactions of Requip and Progesterone, by gender? *:

female:

  1. Influenza like illness
  2. Malaise (a feeling of general discomfort or uneasiness)
  3. Memory impairment
  4. Nausea (feeling of having an urge to vomit)
  5. Headache (pain in head)
  6. Vomiting
  7. Arthralgia (joint pain)
  8. Diarrhoea
  9. Fall
  10. Furuncle (infection of the hair follicle)

male:

  1. Adverse drug reaction
  2. Laryngeal oedema (swelling of larynx)
  3. Personality disorder
  4. Psychotic disorder
  5. Suicidal ideation
  6. Suicide attempt

What are the common drug interactions of Requip and Progesterone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Personality disorder
  2. Psychotic disorder
  3. Suicidal ideation
  4. Suicide attempt
  5. Adverse drug reaction
  6. Inflammation
  7. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

30-39:

  1. Laryngeal oedema (swelling of larynx)
  2. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

40-49:

  1. Depressed mood
  2. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
  3. Infusion site pruritus (severe itching at infusion site)
  4. Infusion site urticaria (rash of round, red welts on the skin at infusion site)
  5. Laryngitis (inflammation of the larynx)
  6. Libido decreased (loss of interest in sex)
  7. Muscle spasms (muscle contraction)
  8. Neck pain
  9. Rhinitis allergic (inflammation of the nasal airways due to allergy)

50-59:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Infection susceptibility increased
  3. Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
  4. Nausea (feeling of having an urge to vomit)
  5. Chondropathy (disease of the cartilage)
  6. Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
  7. Enchondromatosis (multiple enchondromas -- benign masses of cartilage growing within bones)
  8. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  9. Osteonecrosis (death of bone)
  10. Spinal osteoarthritis (joint cartilage loss in spine)

60+:

  1. Memory impairment
  2. Fall
  3. Fracture displacement
  4. Hyperhidrosis (abnormally increased sweating)
  5. Loss of consciousness
  6. Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
  7. Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  8. Muscle atrophy (a decrease in the mass of the muscle)
  9. On and off phenomenon
  10. Osteoporotic fracture (fracture due to weak bone)

What are the existing conditions these people have? *

  1. Osteoporosis (bones weak and more likely to break): 14 people, 24.14%
  2. Pain: 13 people, 22.41%
  3. Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 11 people, 18.97%
  4. Acute Kidney Failure: 10 people, 17.24%
  5. Iron Deficiency: 10 people, 17.24%
  6. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 13.79%
  7. Rickets (softening of bones): 8 people, 13.79%
  8. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 12.07%
  9. Bladder Disorder: 5 people, 8.62%
  10. Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 8.62%

* Approximation only. Some reports may have incomplete information.

Do you take Requip and Progesterone?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Requip and Progesterone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Requip:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Progesterone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Requip and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Progesterone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on ropinirole hydrochloride and progesterone (the active ingredients of Requip and Progesterone, respectively), and Requip and Progesterone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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