Requip and Yaz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Requip (ropinirole hydrochloride) and Yaz (drospirenone; ethinyl estradiol). Common drug interactions include deep vein thrombosis among females and cholelithiasis among males.

The phase IV clinical study analyzes what interactions people have when they take Requip and Yaz. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

What is Yaz?

Yaz has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 41,514 Yaz users. Check the latest studies of Yaz.

On Jul, 08, 2026

62 people who take Requip and Yaz together, and have interactions are studied.

What are the common drug interactions of Requip and Yaz, by gender? *:

female:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gallbladder disorder
Abdominal pain
Abdominal pain upper
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cholecystitis chronic (long lasting infection of gallbladder)
Migraine (headache)
Vomiting
Cerebral infarction (less blood supply to brain resulting tissue damage)
Headache (pain in head)

male:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder injury

What are the common drug interactions of Requip and Yaz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Clonic convulsion (long lasting seizure)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hyperventilation
Incoherent (talking in a confused and unclear way)
Loss of consciousness
Migraine (headache)
Partial seizures (seizures which affect only a part of the brain at onset)
Tremor (trembling or shaking movements in one or more parts of your body)

20-29:

Pain
Injury
Pulmonary embolism (blockage of the main artery of the lung)
Brain compression
Cerebellar infarction (impaired blood circulation to cerebellum)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cholecystitis chronic (long lasting infection of gallbladder)
Emotional distress
Anxiety
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

30-39:

Pain
Pulmonary embolism (blockage of the main artery of the lung)
Injury
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Anxiety
Emotional distress
Cholecystitis chronic (long lasting infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gallbladder disorder
Abdominal pain upper

40-49:

Headache (pain in head)
Abdominal pain upper
Apraxia (disorder that affects a person's ability to organize the movements of the muscles used in speech)
Biliary colic
Clumsiness (a lack of coordination or elegance)
Gallbladder disorder
Migraine (headache)
Muscular weakness (muscle weakness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Speech disorder

50-59:

Pain
Pulmonary embolism (blockage of the main artery of the lung)
Abdominal pain
Abdominal pain lower
Abdominal pain upper
Colitis (inflammation of colon)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Decreased appetite
Diarrhoea haemorrhagic (bloody diarrhoea)
Drug hypersensitivity

60+:

Nausea (feeling of having an urge to vomit)
Abdominal pain
Balance disorder
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bradyarrhythmia (heart slowness)
Cerebral atrophy (decrement in size of brain)
Cerebral haematoma (collection of blood in brain)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain

What are the existing conditions these people have? *

Pain: 15 people, 24.19%
Acne (skin problems that cause pimples): 10 people, 16.13%
Migraine (headache): 7 people, 11.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 8.06%
Depression: 5 people, 8.06%
Stress And Anxiety: 4 people, 6.45%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 6.45%
High Blood Cholesterol: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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