Restasis and Avapro drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Restasis (cyclosporine) and Avapro (irbesartan). Common drug interactions include renal cancer among females and epistaxis among males.
The phase IV clinical study analyzes what interactions people have when they take Restasis and Avapro. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.
What is Restasis?
Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.
What is Avapro?
Avapro has active ingredients of irbesartan. It is often used in high blood pressure. eHealthMe is studying from 19,840 Avapro users. Check the latest studies of Avapro.
96 people who take Restasis and Avapro together, and have interactions are studied.

What are the common drug interactions of Restasis and Avapro, by gender? *:
female:
- Renal cancer (cancer of kidney)
- Speech disorder
- Visual acuity reduced (reduced clearness of vision)
- Asthenia (weakness)
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
- Chronic kidney disease
- Drug ineffective
- Dysgeusia (disorder of the sense of taste)
- Dysphagia (a condition in which swallowing is difficult or painful)
- Dyspnoea (difficult or laboured respiration)
male:
- Epistaxis (bleed from the nose)
- Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
- Chronic kidney disease
- Coagulopathy (blood's ability to clot is impaired)
- Constipation
- Drug effect increased
- Dysphagia (a condition in which swallowing is difficult or painful)
- Enlarged uvula
- Migraine (headache)
- Nephrogenic anaemia (anaemia due to kidney disease)
What are the common drug interactions of Restasis and Avapro, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Bladder disorder
- Blood immunoglobulin e increased
- Dehydration (dryness resulting from the removal of water)
- Herpes simplex (herpes simplex is a common viral infection)
- Human papilloma virus test positive
- Pertussis (whooping cough: a disease of the respiratory mucous membrane)
- Renal disorder (kidney disease)
- Sexually transmitted disease
40-49:
n/a
50-59:
- Renal cancer (cancer of kidney)
- Dysphagia (a condition in which swallowing is difficult or painful)
- Incision site pain
- Nephrolithiasis (calculi in the kidneys)
- Vomiting
- Chest discomfort
- Disease recurrence
- Muscle spasms (muscle contraction)
- Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
- Cough
60+:
- Malaise (a feeling of general discomfort or uneasiness)
- Nephrosclerosis (hardening of the kidney due to renovascular disease)
- Weight decreased
- Abdominal hernia
- Activities of daily living impaired
- Allergic sinusitis
- Arrhythmia (irregular heartbeat)
- Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
- Blood parathyroid hormone increased
- Cholecystitis (infection of gallbladder)
What are the existing conditions these people have? *
- Depression: 12 people, 12.50%
- High Blood Cholesterol: 11 people, 11.46%
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 9.38%
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 9.38%
- Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 8.33%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 6.25%
- Immunodeficiency Common Variable: 5 people, 5.21%
* Approximation only. Some reports may have incomplete information.
Do you take Restasis and Avapro?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Restasis and Avapro:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Restasis:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Avapro:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Restasis and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Avapro and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on cyclosporine and irbesartan (the active ingredients of Restasis and Avapro, respectively), and Restasis and Avapro (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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