Restasis and Butrans drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Restasis (cyclosporine) and Butrans (buprenorphine). Common drug interactions include headache among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Restasis and Butrans. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Restasis?

Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.

What is Butrans?

Butrans has active ingredients of buprenorphine. It is often used in pain. eHealthMe is studying from 64,148 Butrans users. Check the latest studies of Butrans.

On Jul, 07, 2026

33 people who take Restasis and Butrans together, and have interactions are studied.

What are the common drug interactions of Restasis and Butrans, by gender? *:

female:

Headache (pain in head)
Drug ineffective
Anxiety
Depression
Dyspnoea (difficult or laboured respiration)
Heart rate increased
Hyperhidrosis (abnormally increased sweating)
Malaise (a feeling of general discomfort or uneasiness)
Overdose
Somnolence (a state of near-sleep, a strong desire for sleep)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Rib fracture
Spinal fracture (fracture in one of vertebrae)
Bone density decreased
Constipation
Emotional distress
Hypersomnia (excessive daytime sleepiness (eds))
Impaired work ability
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Restasis and Butrans, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Disability
Psychiatric symptom

30-39:

n/a

40-49:

Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Anxiety
Arthralgia (joint pain)
Blood pressure decreased
Blood pressure increased
Depression
Drug ineffective
Feeling hot
Fluid retention (an abnormal accumulation of fluid in the blood)

50-59:

Hot flush (sudden feelings of heat)
Hunger

60+:

Renal failure (kidney dysfunction)
Anaemia (lack of blood)
Mouth ulceration (mouth ulcers)
Nephrogenic anaemia (anaemia due to kidney disease)
Oropharyngeal pain
Peripheral swelling
Renal disorder (kidney disease)
Renal impairment (severely reduced kidney function)
Skin warm
Cellulitis (infection under the skin)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 42.42%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 18.18%
Stress And Anxiety: 5 people, 15.15%
Muscle Spasms (muscle contraction): 4 people, 12.12%
Insomnia (sleeplessness): 4 people, 12.12%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 12.12%
Migraine (headache): 3 people, 9.09%
High Blood Cholesterol: 3 people, 9.09%
Infection: 3 people, 9.09%
Irritable Bowel Syndrome: 3 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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