Restasis and Ingrezza drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Restasis (cyclosporine) and Ingrezza (valbenazine tosylate). Common drug interactions include bradyphrenia among females and dystonia among males.
The phase IV clinical study analyzes what interactions people have when they take Restasis and Ingrezza. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.
What is Restasis?
Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.
What is Ingrezza?
Ingrezza has active ingredients of valbenazine tosylate. eHealthMe is studying from 23,666 Ingrezza users. Check the latest studies of Ingrezza.
17 people who take Restasis and Ingrezza together, and have interactions are studied.

What are the common drug interactions of Restasis and Ingrezza, by gender? *:
female:
- Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
- Dementia (madness)
- Depressed mood
- Dry skin
- Eyelid margin crusting (crusting at the lid margins, generally worse on waking)
- Eyelid pain
- Hyperhidrosis (abnormally increased sweating)
- Photophobia (extreme sensitivity to light)
- Septic shock (shock due to blood infection)
- Shoulder operation
male:
- Dystonia (abnormal muscle tone)
- Restlessness (not able to rest)
- Somnolence (a state of near-sleep, a strong desire for sleep)
What are the common drug interactions of Restasis and Ingrezza, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
n/a
60+:
- Death
- Insomnia (sleeplessness)
- Parkinsonian gait (gait exhibited by patients suffering from parkinson's disease)
- Dementia (madness)
- Dry skin
- Dystonia (abnormal muscle tone)
- Eyelid margin crusting (crusting at the lid margins, generally worse on waking)
- Eyelid pain
- Photophobia (extreme sensitivity to light)
- Shoulder operation
What are the existing conditions these people have? *
- Tardive Dyskinesia (a disorder that involves involuntary movements): 14 people, 82.35%
- Stress And Anxiety: 3 people, 17.65%
- Depression: 3 people, 17.65%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.76%
- High Blood Pressure: 2 people, 11.76%
- Wheezing (a high-pitched whistling sound made while you breath): 1 person, 5.88%
- Diabetes: 1 person, 5.88%
- Glaucoma (increased fluid pressure in the eye with vision loss): 1 person, 5.88%
- Gastrointestinal Hypomotility (less activity of the intestinal tract): 1 person, 5.88%
- Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 5.88%
* Approximation only. Some reports may have incomplete information.
Do you take Restasis and Ingrezza?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Restasis and Ingrezza:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Restasis:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Ingrezza:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Restasis and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Ingrezza and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on cyclosporine and valbenazine tosylate (the active ingredients of Restasis and Ingrezza, respectively), and Restasis and Ingrezza (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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