Restasis and Plegridy drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Restasis (cyclosporine) and Plegridy (peginterferon beta-1a). Common drug interactions include depression among females.
The phase IV clinical study analyzes what interactions people have when they take Restasis and Plegridy. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.
What is Restasis?
Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.
What is Plegridy?
Plegridy has active ingredients of peginterferon beta-1a. eHealthMe is studying from 14,764 Plegridy users. Check the latest studies of Plegridy.
15 people who take Restasis and Plegridy together, and have interactions are studied.

What are the common drug interactions of Restasis and Plegridy, by gender? *:
female:
- Depression
- Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
- Monoclonal immunoglobulin present
- Chest pain
- Pyrexia (fever)
- Skin disorder (skin disease)
- Therapeutic response unexpected
- Anxiety
- Fall
- Gait disturbance
male:
n/a
What are the common drug interactions of Restasis and Plegridy, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Abdominal pain
- Alcohol abuse
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Anxiety
- Arachnoiditis (neuropathic disease caused by inflammation of the arachnoid)
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
- Cataract (clouding of the lens inside the eye)
- Cerebral haemorrhage (bleeding within the brain)
- Contusion (a type of hematoma of tissue in which capillaries)
- Cystitis (inflammation of the wall of the bladder)
50-59:
- Asthenia (weakness)
- Gait disturbance
- Muscular weakness (muscle weakness)
60+:
- Abdominal discomfort
- Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
- Headache (pain in head)
- Hemiparesis (weakness on one side of the body)
- Hyperlipidaemia (presence of excess lipids in the blood)
- Impaired gastric emptying
- Influenza
- Insomnia (sleeplessness)
- Limb injury
- Micturition urgency (urgency to pass the urine)
What are the existing conditions these people have? *
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 66.67%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 20.00%
- Gait Disturbance: 3 people, 20.00%
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 20.00%
- Sleep Disorder: 2 people, 13.33%
- Weakness: 1 person, 6.67%
- High Blood Pressure: 1 person, 6.67%
- Depression: 1 person, 6.67%
- Diarrhea: 1 person, 6.67%
- Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 1 person, 6.67%
* Approximation only. Some reports may have incomplete information.
Do you take Restasis and Plegridy?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Restasis and Plegridy:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Restasis:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Plegridy:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Restasis and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Plegridy and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on cyclosporine and peginterferon beta-1a (the active ingredients of Restasis and Plegridy, respectively), and Restasis and Plegridy (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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