Restasis and Rinvoq drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Restasis (cyclosporine) and Rinvoq (upadacitinib). Common drug interactions include surgery among females and adverse drug reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Restasis and Rinvoq. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Restasis?

Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.

What is Rinvoq?

Rinvoq has active ingredients of upadacitinib. eHealthMe is studying from 47,375 Rinvoq users. Check the latest studies of Rinvoq.

On Jul, 12, 2026

60 people who take Restasis and Rinvoq together, and have interactions are studied.

What are the common drug interactions of Restasis and Rinvoq, by gender? *:

female:

Surgery
Nausea (feeling of having an urge to vomit)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Headache (pain in head)
Vomiting
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain in extremity
Gait disturbance
Neoplasm malignant (cancer tumour)
Asthenia (weakness)

male:

Adverse drug reaction
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Drug hypersensitivity
Eye pain
Genital pain (pain in genital)
Hepatic steatosis (fatty liver disease)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Pain
Pyrexia (fever)

What are the common drug interactions of Restasis and Rinvoq, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Surgery
Pain
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

50-59:

Sinusitis (inflammation of sinus)
Headache (pain in head)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Skin cancer
Acne (skin problems that cause pimples)
Allergy to arthropod sting
Arthropod sting (arthropod bite)
Cardiac disorder
Contusion (a type of hematoma of tissue in which capillaries)

60+:

Pain
Gait disturbance
Pneumonia
Pulmonary mass
Renal cancer (cancer of kidney)
Thyroid mass
Ageusia (loss of taste functions of the tongue)
Anosmia (partial or complete loss of the sense of smell)
Headache (pain in head)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 43 people, 71.67%
High Blood Pressure: 7 people, 11.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 10.00%
High Blood Cholesterol: 5 people, 8.33%
Osteoporosis (bones weak and more likely to break): 4 people, 6.67%
Muscle Spasms (muscle contraction): 4 people, 6.67%
Hypersensitivity: 4 people, 6.67%
Glaucoma (increased fluid pressure in the eye with vision loss): 4 people, 6.67%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 5.00%
Pain: 3 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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