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Restoril and Xgeva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Restoril (temazepam) and Xgeva (denosumab). Common drug interactions include pulmonary mass among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Restoril and Xgeva. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Restoril?

Restoril has active ingredients of temazepam. It is often used in insomnia. eHealthMe is studying from 13,522 Restoril users. Check the latest studies of Restoril.

What is Xgeva?

Xgeva has active ingredients of denosumab. It is often used in breast cancer. eHealthMe is studying from 37,717 Xgeva users. Check the latest studies of Xgeva.

On Jul, 14, 2026

32 people who take Restoril and Xgeva together, and have interactions are studied.

Restoril and Xgeva drug interactions.

What are the common drug interactions of Restoril and Xgeva, by gender? *:

female:

  1. Pulmonary mass
  2. Renal impairment (severely reduced kidney function)
  3. Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
  4. Vomiting
  5. Pain in jaw
  6. Tooth abscess (pus formation in tooth)
  7. Tooth fracture
  8. Toothache (tooth pain)
  9. Abdominal discomfort
  10. Abdominal pain

male:

  1. Death
  2. Diarrhoea
  3. Back pain
  4. Exposed bone in jaw
  5. Impaired healing
  6. Metastases to central nervous system (cancer spreads to central nervous system)
  7. Prostatic specific antigen increased
  8. Stomatitis (inflammation of mucous membrane of mouth)
  9. Teeth brittle (other half has a defect in the teeth)
  10. Tooth abscess (pus formation in tooth)

What are the common drug interactions of Restoril and Xgeva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Fatigue (feeling of tiredness)
  2. Arthralgia (joint pain)
  3. Tooth fracture
  4. Toothache (tooth pain)
  5. Constipation
  6. Diarrhoea
  7. Disease progression
  8. Dizziness
  9. Gangrene (body tissue dies)
  10. Gastric ulcer (stomach ulcer)

What are the existing conditions these people have? *

  1. Metastases To Bone (cancer spreads to bone): 7 people, 21.88%
  2. Nausea (feeling of having an urge to vomit): 4 people, 12.50%
  3. Breast Cancer Metastatic: 4 people, 12.50%
  4. Lung Neoplasm Malignant (cancer tumour of lung): 4 people, 12.50%
  5. Thrombocytopenia (decrease of platelets in blood): 4 people, 12.50%
  6. Prostate Cancer Metastatic: 4 people, 12.50%
  7. Renal Cell Carcinoma (a kidney cancer): 4 people, 12.50%
  8. Sleep Disorder: 4 people, 12.50%
  9. Anaemia (lack of blood): 4 people, 12.50%
  10. Pain: 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

Do you take Restoril and Xgeva?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Restoril and Xgeva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Restoril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Xgeva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Restoril and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Xgeva and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on temazepam and denosumab (the active ingredients of Restoril and Xgeva, respectively), and Restoril and Xgeva (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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