Retin-a and Valacyclovir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Retin-a (tretinoin) and Valacyclovir (valacyclovir hydrochloride). Common drug interactions include cognitive disorder among females and ocular icterus among males.

The phase IV clinical study analyzes what interactions people have when they take Retin-a and Valacyclovir. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Retin-a?

Retin-a has active ingredients of tretinoin. It is often used in acne. eHealthMe is studying from 2,475 Retin-a users. Check the latest studies of Retin-a.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,108 Valacyclovir users. Check the latest studies of Valacyclovir.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

12 people who take Retin-a and Valacyclovir together, and have interactions are studied.

Retin-a and Valacyclovir drug interactions.

What are the common drug interactions of Retin-A and Valacyclovir, by gender? *:

female:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Iron deficiency
Nasal septum deviation (deviated nasal septum)
Pain
Lymph node calcification (calcium deposit in lymph node)
Silicosis (a lung disease that is caused by inhaling tiny bits of silica)
Ulcer haemorrhage (bleeding ulcer)
Adverse drug reaction
Blood potassium decreased
Erythema (redness of the skin)

male:

Ocular icterus (presence of jaundice seen in the sclera of the eye)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased
Chronic kidney disease
Emotional distress
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Pain
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Retin-A and Valacyclovir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Ocular icterus (presence of jaundice seen in the sclera of the eye)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Sinusitis (inflammation of sinus)

30-39:

n/a

40-49:

Iron deficiency
Nasal septum deviation (deviated nasal septum)
Pain
Silicosis (a lung disease that is caused by inhaling tiny bits of silica)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Accident at work
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased
Chronic kidney disease
Emotional distress
Pain
Renal impairment (severely reduced kidney function)

60+:

Spinal column injury (spinal cord bone injury)

What are the existing conditions these people have? *

Drowsiness: 5 people, 41.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 16.67%
Multiple Myeloma (cancer of the plasma cells): 2 people, 16.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 16.67%
Hiv Infection: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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