Rexulti and Aleve drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rexulti (brexpiprazole) and Aleve (naproxen sodium). Common drug interactions include suicidal ideation among females and somnolence among males.

The phase IV clinical study analyzes what interactions people have when they take Rexulti and Aleve. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Rexulti?

Rexulti has active ingredients of brexpiprazole. It is often used in major depression. eHealthMe is studying from 13,394 Rexulti users. Check the latest studies of Rexulti.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

On Jul, 06, 2026

32 people who take Rexulti and Aleve together, and have interactions are studied.

What are the common drug interactions of Rexulti and Aleve, by gender? *:

female:

Suicidal ideation
Clavicle fracture
Cough
Erythema (redness of the skin)
Memory impairment
Osteoporosis (bones weak and more likely to break)
Surgery
Weight increased
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Depression

male:

Somnolence (a state of near-sleep, a strong desire for sleep)
Confusional state
Pain in extremity
Paralysis
Parkinson's disease
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Stress
Surgery
Tremor (trembling or shaking movements in one or more parts of your body)
Urticaria (rash of round, red welts on the skin that itch intensely)

What are the common drug interactions of Rexulti and Aleve, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug ineffective
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

30-39:

Somnolence (a state of near-sleep, a strong desire for sleep)
Confusional state
Encephalopathy (functioning of the brain is affected by some agent or condition)
Lung disorder (lung disease)
Nausea (feeling of having an urge to vomit)
Stress
Abdominal pain upper
Adjustment disorder with depressed mood
Anxiety
Asthenia (weakness)

40-49:

Glossodynia (a burning or painful sensation in the tongue)

50-59:

Alopecia (absence of hair from areas of the body)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Myalgia (muscle pain)
Paralysis
Sleep disorder
Muscle spasms (muscle contraction)
Pain in extremity
Back pain
Depression

60+:

Weight increased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 20 people, 62.50%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 16 people, 50.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 12.50%
Drowsiness: 4 people, 12.50%
Migraine (headache): 3 people, 9.38%
Depression: 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

Do you take Rexulti and Aleve?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously