Rexulti and Chantix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rexulti (brexpiprazole) and Chantix (varenicline tartrate). Common drug interactions include hiatus hernia among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Rexulti and Chantix. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Rexulti?

Rexulti has active ingredients of brexpiprazole. It is often used in major depression. eHealthMe is studying from 13,394 Rexulti users. Check the latest studies of Rexulti.

What is Chantix?

Chantix has active ingredients of varenicline tartrate. It is often used in quit smoking. eHealthMe is studying from 89,889 Chantix users. Check the latest studies of Chantix.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 03, 2026

28 people who take Rexulti and Chantix together, and have interactions are studied.

What are the common drug interactions of Rexulti and Chantix, by gender? *:

female:

Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Haematuria (presence of blood in urine)
Acute respiratory distress syndrome
Acute respiratory failure
Disturbance in attention
Embolic stroke (stroke due to obstruction due to an embolus)
Nightmare (unpleasant dream)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Foot fracture
Vertigo
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Antisocial behaviour
Depression
Chronic kidney disease
Emotional distress
Osteoporosis (bones weak and more likely to break)

What are the common drug interactions of Rexulti and Chantix, by age (0-1 to 60+)? *:

0-1:

Death

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Somnolence (a state of near-sleep, a strong desire for sleep)
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Abdominal distension
Bell's palsy (facial paralysis)
Death
Drug ineffective
Genital herpes (herpes infection of genital)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypertension (high blood pressure)
Intestinal obstruction

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Osteoporosis (bones weak and more likely to break)
Pain
Renal tubular necrosis (death of kidney tubules)
Bone density decreased
Renal failure (kidney dysfunction)
Disturbance in attention

60+:

Acute respiratory distress syndrome
Acute respiratory failure
Weight decreased
Embolic stroke (stroke due to obstruction due to an embolus)
Pneumonia escherichia (pneumonia due to bacteria escherichia coli)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Septic shock (shock due to blood infection)
Sinus bradycardia (an unusually slow heartbeat due to heart disease)
Tricuspid valve incompetence (inefficient heart valve)
Asthenia (weakness)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 39.29%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 21.43%
Hiv Infection: 4 people, 14.29%
Prostate Cancer: 2 people, 7.14%
Depression: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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