Rexulti and Colace drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rexulti (brexpiprazole) and Colace (docusate ). Common drug interactions include muscle spasms among females and appetite disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Rexulti and Colace. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Rexulti?

Rexulti has active ingredients of brexpiprazole. It is often used in major depression. eHealthMe is studying from 13,394 Rexulti users. Check the latest studies of Rexulti.

What is Colace?

Colace has active ingredients of docusate . It is often used in constipation. eHealthMe is studying from 41,841 Colace users. Check the latest studies of Colace.

On Jul, 11, 2026

42 people who take Rexulti and Colace together, and have interactions are studied.

What are the common drug interactions of Rexulti and Colace, by gender? *:

female:

Muscle spasms (muscle contraction)
Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Pneumonia
Productive cough
Renal impairment (severely reduced kidney function)
Saliva discolouration (change in colour of saliva)
Skin cancer
Spinal cord injury

male:

Appetite disorder (abnormal eating habits)
Blood glucose increased
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Increased appetite
Micturition urgency (urgency to pass the urine)
Prostate infection
Restless legs syndrome (a powerful urge to move your legs)
Weight increased
Dizziness
Peripheral swelling

What are the common drug interactions of Rexulti and Colace, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Nausea (feeling of having an urge to vomit)
Abnormal sleep-related event
Balance disorder
Borderline personality disorder
Dizziness
Feeling drunk
Headache (pain in head)
Hospitalisation
Hypertension (high blood pressure)
Memory impairment

40-49:

Cystitis (inflammation of the wall of the bladder)
Hospitalisation
Memory impairment
Spinal fusion surgery
Diplopia (double vision)
Hysterectomy
Pain
Poor quality sleep
Retinal vascular disorder (a range of eye diseases that affect the blood vessels in the eye)
Asthma

50-59:

Appetite disorder (abnormal eating habits)
Blood glucose increased
Calculus bladder (bladder stone)
Cystitis (inflammation of the wall of the bladder)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Feeling hot
Headache (pain in head)

60+:

Dizziness
Peripheral swelling
Blood pressure increased
Chronic kidney disease
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Decreased activity
Emotional distress
Frequent bowel movements
Malaise (a feeling of general discomfort or uneasiness)
Osteoporosis (bones weak and more likely to break)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 22 people, 52.38%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 33.33%
Drowsiness: 7 people, 16.67%
Stress And Anxiety: 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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