Rexulti and Sunosi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rexulti (brexpiprazole) and Sunosi (solriamfetol). Common drug interactions include depression among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Rexulti and Sunosi. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Rexulti?

Rexulti has active ingredients of brexpiprazole. It is often used in major depression. eHealthMe is studying from 13,394 Rexulti users. Check the latest studies of Rexulti.

What is Sunosi?

Sunosi has active ingredients of solriamfetol. eHealthMe is studying from 2,936 Sunosi users. Check the latest studies of Sunosi.

On Jul, 05, 2026

38 people who take Rexulti and Sunosi together, and have interactions are studied.

What are the common drug interactions of Rexulti and Sunosi, by gender? *:

female:

Depression
Fatigue (feeling of tiredness)
Blood glucose fluctuation
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Nocturia (the need to get up in the night to urinate)
Obesity (having too much body fat)
Osteoporosis (bones weak and more likely to break)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Tardive dyskinesia (a disorder that involves involuntary movements)

male:

Dyspnoea (difficult or laboured respiration)
Mood altered (changes in mood)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Suicidal ideation
Tremor (trembling or shaking movements in one or more parts of your body)
Blood glucose increased
Confusional state
Encephalopathy (functioning of the brain is affected by some agent or condition)
Lung disorder (lung disease)
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the common drug interactions of Rexulti and Sunosi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Depression
Hospitalisation
Borderline personality disorder
Suicidal ideation

30-39:

Confusional state
Encephalopathy (functioning of the brain is affected by some agent or condition)
Lung disorder (lung disease)
Somnolence (a state of near-sleep, a strong desire for sleep)
Surgery

40-49:

Bradycardia (abnormally slow heart action)
Cardiac disorder
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Stress cardiomyopathy (stress-induced chronic disease of the heart muscle)

50-59:

Blood glucose fluctuation
Depression
Immobile (not moving)
Neurosurgery
Fall
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Arthropathy
Food craving
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Dyspnoea (difficult or laboured respiration)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 34 people, 89.47%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 18 people, 47.37%
Drowsiness: 11 people, 28.95%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 4 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Rexulti and Sunosi?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously