Rexulti and Venlafaxine hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rexulti (brexpiprazole) and Venlafaxine hydrochloride (venlafaxine hydrochloride). Common drug interactions include dizziness among females and malaise among males.

The phase IV clinical study analyzes what interactions people have when they take Rexulti and Venlafaxine hydrochloride. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Rexulti?

Rexulti has active ingredients of brexpiprazole. It is often used in major depression. eHealthMe is studying from 13,394 Rexulti users. Check the latest studies of Rexulti.

What is Venlafaxine hydrochloride?

Venlafaxine hydrochloride has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 17,915 Venlafaxine hydrochloride users. Check the latest studies of Venlafaxine hydrochloride.

On Jul, 06, 2026

11 people who take Rexulti and Venlafaxine hydrochloride together, and have interactions are studied.

Rexulti and Venlafaxine hydrochloride drug interactions.

What are the common drug interactions of Rexulti and Venlafaxine Hydrochloride, by gender? *:

female:

Dizziness
Irritability
Migraine (headache)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tension headache
Pain
Abdominal pain upper
Agitation (state of anxiety or nervous excitement)
Alopecia (absence of hair from areas of the body)
Altered state of consciousness (altered state of mind)

male:

Malaise (a feeling of general discomfort or uneasiness)
Spasmodic dysphonia (a voice disorder characterized by involuntary movements or spasms of one or more muscles of the larynx)
Dysphagia (a condition in which swallowing is difficult or painful)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Glycosuria (excretion of glucose into the urine)
Gynaecomastia (enlargement of the gland tissue of the male breast)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hallucination, tactile (sensation of physical contact with an object that isn't there)
Hallucination, visual (seeing things that aren't there)
Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)

What are the common drug interactions of Rexulti and Venlafaxine Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Spasmodic dysphonia (a voice disorder characterized by involuntary movements or spasms of one or more muscles of the larynx)
Alcohol abuse
Antipsychotic drug level increased
C-reactive protein increased
Chest discomfort
Delusion (a false belief or opinion)
Drug ineffective
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Gynaecomastia (enlargement of the gland tissue of the male breast)
Hallucination, auditory (perceiving sounds without auditory stimulus)

40-49:

Blood creatine phosphokinase increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Glycosuria (excretion of glucose into the urine)

50-59:

Alopecia (absence of hair from areas of the body)
Crying
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Fear
Feeling of despair
Headache (pain in head)
Hypoglycaemia (deficiency of glucose in the bloodstream)

60+:

Dizziness
Irritability
Migraine (headache)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tension headache
Altered state of consciousness (altered state of mind)
Hypokalaemia (low potassium)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

What are the existing conditions these people have? *

Stress And Anxiety: 2 people, 18.18%
Tooth Abscess (pus formation in tooth): 1 person, 9.09%
Hyperprolactinaemia (abnormally high levels of prolactin in the blood): 1 person, 9.09%
Asthma: 1 person, 9.09%
Diarrhea: 1 person, 9.09%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 9.09%
Gastric Disorder (disease of stomach): 1 person, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 9.09%
High Blood Cholesterol: 1 person, 9.09%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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