Rexulti and Zofran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rexulti (brexpiprazole) and Zofran (ondansetron hydrochloride). Common drug interactions include gastrointestinal disorder among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Rexulti and Zofran. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Rexulti?

Rexulti has active ingredients of brexpiprazole. It is often used in major depression. eHealthMe is studying from 13,394 Rexulti users. Check the latest studies of Rexulti.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

On Jul, 04, 2026

96 people who take Rexulti and Zofran together, and have interactions are studied.

What are the common drug interactions of Rexulti and Zofran, by gender? *:

female:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
General physical health deterioration (weak health status)
Intentional self-injury
Lower respiratory tract infection
Malaise (a feeling of general discomfort or uneasiness)
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Muscular weakness (muscle weakness)
Staphylococcal infection (an infection with staphylococcus bacteria)
Weight increased

male:

Pain
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Anxiety
Asthenia (weakness)
Blood creatinine increased
Blood glucose increased
Blood phosphorus decreased
Blood urea increased
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Change of bowel habit

What are the common drug interactions of Rexulti and Zofran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Atelectasis (partial or complete collapse of the lung)
Blood iron decreased
Cardiac murmur (an heart sound in valve abnormality)
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)
Constipation
Cough
Dizziness
Folliculitis (infection of hair root)
Haematuria (presence of blood in urine)

20-29:

Lactation disorder
Cough
Diarrhoea
Infusion site rash
Pyrexia (fever)
Urinary tract infection
Viral upper respiratory tract infection

30-39:

Somnolence (a state of near-sleep, a strong desire for sleep)
Anxiety
Insomnia (sleeplessness)
Abdominal pain upper
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Asthenia (weakness)
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chronic kidney disease

40-49:

Hypotension (abnormally low blood pressure)
Intentional self-injury
Lower limb fracture
Lower respiratory tract infection
Malaise (a feeling of general discomfort or uneasiness)
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Migraine (headache)
Pain in jaw

50-59:

Fall
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Blood prolactin increased
Diplopia (double vision)
Drug ineffective
Drug intolerance (drug sensitivity)
Urinary retention (the inability to completely or partially empty the bladder)

60+:

Pain
Bacteraemia (presence of bacteria in the blood)
Respiratory tract infection viral
Anxiety
Bacterial infection
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hypotension (abnormally low blood pressure)
Osteoporosis (bones weak and more likely to break)
Seasonal allergy (allergic condition due to certain season)
Abdominal pain upper

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 17 people, 17.71%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 16.67%
Depression: 11 people, 11.46%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 11.46%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 7.29%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 6.25%
Nausea And Vomiting: 5 people, 5.21%
Migraine (headache): 5 people, 5.21%
Drowsiness: 5 people, 5.21%

* Approximation only. Some reports may have incomplete information.

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