Rezulin and Estrace drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rezulin (troglitazone) and Estrace (estradiol). Common drug interactions include hepatic cirrhosis among females.

The phase IV clinical study analyzes what interactions people have when they take Rezulin and Estrace. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Rezulin?

Rezulin has active ingredients of troglitazone. eHealthMe is studying from 8,764 Rezulin users. Check the latest studies of Rezulin.

What is Estrace?

Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 16,703 Estrace users. Check the latest studies of Estrace.

On Aug, 02, 2026

67 people who take Rezulin and Estrace together, and have interactions are studied.

What are the common drug interactions of Rezulin and Estrace, by gender? *:

female:

Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic failure (liver failure)
Liver fatty (fat deposition of liver)
Oesophageal varices (extremely dilated sub-mucosal veins in the lower third of the oesophagus)
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)
Autoimmune hepatitis
Encephalopathy (functioning of the brain is affected by some agent or condition)
Haematemesis (vomiting of blood)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Renal tubular necrosis (death of kidney tubules)

male:

n/a

What are the common drug interactions of Rezulin and Estrace, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Liver fatty (fat deposition of liver)
Vaginal candidiasis (vaginal fungal infection)
Inflammation
Abdominal pain
Aspartate aminotransferase increased
Chest pain
Constipation
Depression
Diarrhoea

40-49:

Alanine aminotransferase increased
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Nausea (feeling of having an urge to vomit)
Aspartate aminotransferase increased
Blood bilirubin increased
Blood lactate dehydrogenase increased
Fatigue (feeling of tiredness)
Hepatic failure (liver failure)
Hepatitis (inflammation of the liver)
Malaise (a feeling of general discomfort or uneasiness)

50-59:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Oedema (fluid collection in tissue)
Oedema lower limb (fluid collection in tissue of lower leg)
Renal cyst (kidney cyst)
Acidosis (build-up of carbon dioxide in the blood)
Aortic atherosclerosis (degenerative process of aortic arteries)
Asthma

60+:

Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic failure (liver failure)
Ascites (accumulation of fluid in the abdominal cavity)
Coma (state of unconsciousness lasting more than six hours)
Dysphagia (a condition in which swallowing is difficult or painful)
Oesophageal varices (extremely dilated sub-mucosal veins in the lower third of the oesophagus)
Oesophagitis (inflammation of oesophagus)
Urinary bladder haemorrhage (urinary bladder bleeding)
Blood bilirubin increased
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

* Approximation only. Some reports may have incomplete information.

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