Ribasphere and Tramadol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ribasphere (ribavirin) and Tramadol (tramadol hydrochloride). Common drug interactions include asthenia among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Ribasphere and Tramadol. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Ribasphere?

Ribasphere has active ingredients of ribavirin. It is often used in hepatitis c. eHealthMe is studying from 9,336 Ribasphere users. Check the latest studies of Ribasphere.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,798 Tramadol users. Check the latest studies of Tramadol.



On Jul, 19, 2026

92 people who take Ribasphere and Tramadol together, and have interactions are studied.

Ribasphere and Tramadol drug interactions.

What are the common drug interactions of Ribasphere and Tramadol, by gender? *:

female:

  1. Asthenia (weakness)
  2. Decreased appetite
  3. Dizziness
  4. Rash
  5. Diarrhoea
  6. Anxiety
  7. Mood swings (an extreme or rapid change in mood)
  8. Alopecia (absence of hair from areas of the body)
  9. Pruritus (severe itching of the skin)
  10. Stomatitis (inflammation of mucous membrane of mouth)

male:

  1. Fatigue (feeling of tiredness)
  2. Nausea (feeling of having an urge to vomit)
  3. Asthenia (weakness)
  4. Dysgeusia (disorder of the sense of taste)
  5. Dyspnoea (difficult or laboured respiration)
  6. Insomnia (sleeplessness)
  7. Irritability
  8. Pain in extremity
  9. Pruritus (severe itching of the skin)
  10. Chest pain

What are the common drug interactions of Ribasphere and Tramadol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Headache (pain in head)
  2. Anxiety
  3. Dry skin
  4. Fatigue (feeling of tiredness)
  5. Insomnia (sleeplessness)
  6. Nausea (feeling of having an urge to vomit)
  7. Pruritus (severe itching of the skin)
  8. Pruritus allergic (severe allergic itching of the skin)
  9. Rash
  10. Migraine (headache)

30-39:

  1. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  2. Blood pressure increased
  3. Bone pain
  4. Chills (felling of cold)
  5. Contusion (a type of hematoma of tissue in which capillaries)
  6. Decreased appetite
  7. Diarrhoea
  8. Gingival bleeding (bleeding gums)
  9. Headache (pain in head)
  10. Insomnia (sleeplessness)

40-49:

  1. Asthenia (weakness)
  2. Fatigue (feeling of tiredness)
  3. Nausea (feeling of having an urge to vomit)
  4. Visual impairment
  5. Epistaxis (bleed from the nose)
  6. Insomnia (sleeplessness)
  7. Dizziness
  8. Eating disorder
  9. Nasal oedema (fluid collection in nose)
  10. Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)

50-59:

  1. Swelling
  2. Swelling face
  3. Swollen tongue (swelling of tongue)
  4. Vision blurred
  5. Abdominal discomfort
  6. Abdominal pain
  7. Adverse event
  8. Agitation (state of anxiety or nervous excitement)
  9. Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
  10. Apathy

60+:

  1. Fatigue (feeling of tiredness)
  2. Decreased appetite
  3. Abdominal distension
  4. Anorectal discomfort
  5. Asthenia (weakness)
  6. Balance disorder
  7. Diarrhoea
  8. Drug administration error
  9. Dysgeusia (disorder of the sense of taste)
  10. Ear infection

What are the existing conditions these people have? *

  1. Hypersensitivity: 5 people, 5.43%

* Approximation only. Some reports may have incomplete information.

Do you take Ribasphere and Tramadol?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Ribasphere and Tramadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ribasphere:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Tramadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ribasphere and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tramadol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on ribavirin and tramadol hydrochloride (the active ingredients of Ribasphere and Tramadol, respectively), and Ribasphere and Tramadol (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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