Rinvoq and Tacrolimus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rinvoq (upadacitinib) and Tacrolimus (tacrolimus). Common drug interactions include myelosuppression among females and squamous cell carcinoma among males.

The phase IV clinical study analyzes what interactions people have when they take Rinvoq and Tacrolimus. It is created by eHealthMe based on reports of 94 people who take the same drugs from the FDA, and is updated regularly.

What is Rinvoq?

Rinvoq has active ingredients of upadacitinib. eHealthMe is studying from 47,375 Rinvoq users. Check the latest studies of Rinvoq.

What is Tacrolimus?

Tacrolimus has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 116,160 Tacrolimus users. Check the latest studies of Tacrolimus.

On Aug, 01, 2026

94 people who take Rinvoq and Tacrolimus together, and have interactions are studied.

Rinvoq and Tacrolimus drug interactions.

What are the common drug interactions of Rinvoq and Tacrolimus, by gender? *:

female:

Myelosuppression (a decrease in the production of blood cells)
Renal impairment (severely reduced kidney function)
Skin fissures (a crack in the skin)
Spinal compression fracture (fracture due to spinal compression on bone)
Dysphonia (speech disorder attributable to a disorder of phonation)
Herpes zoster
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Pain in extremity
Acne (skin problems that cause pimples)
Allergy to arthropod sting

male:

Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Drug ineffective
Cellulitis (infection under the skin)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Death
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Fistula (an abnormal connection or passageway between two)
Headache (pain in head)
Sepsis (a severe blood infection that can lead to organ failure and death)
Skin cancer

What are the common drug interactions of Rinvoq and Tacrolimus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Bacterial infection
Cellulitis (infection under the skin)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Discomfort
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Pneumonia mycoplasmal (mycoplasma pneumonia (mp) is a contagious respiratory infection)
Rash
Skin discomfort (skin pain/irritation)
Skin erosion (a discontinuity of the skin)

20-29:

Puncture site induration
Alanine aminotransferase increased
Aspartate aminotransferase increased
Avulsion fracture (bone fracture)
Blood lactate dehydrogenase increased
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Liver disorder (liver diseases)
Upper limb fracture
Conjunctivitis (pink eye)

30-39:

Rash
Dyspnoea (difficult or laboured respiration)
Eye irritation
Eye swelling
Hypersensitivity
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Colitis ulcerative (inflammation of colon with ulcer)
Drug eruption (adverse drug reaction of the skin)
Erythema (redness of the skin)
Frequent bowel movements

40-49:

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eye inflammation
Eye pruritus (eye itching)
Eye swelling
Skin fissures (a crack in the skin)

50-59:

Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Skin discolouration (change of skin colour)
Skin infection
Urinary tract infection
Arthralgia (joint pain)
Colitis ulcerative (inflammation of colon with ulcer)
Cytomegalovirus enterocolitis (virus infection of intestine and colon)
Cytomegalovirus infection

60+:

Drug ineffective
Arthralgia (joint pain)
Oesophageal ulcer (ulcer of oesophagus)
Oral lichen planus (a chronic inflammatory disease that causes bilateral white striations, papules, or plaques on the buccal mucosa)
Skin lesion
Tongue ulceration (ulcers on tongue)
Weight decreased
Colon cancer
Adverse drug reaction
Haemoglobin decreased

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 52 people, 55.32%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 17 people, 18.09%
High Blood Pressure: 6 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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