Risperdal and Diastat drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Risperdal (risperidone) and Diastat (diazepam). Common drug interactions include convulsion among females and allergy to arthropod sting among males.
The phase IV clinical study analyzes what interactions people have when they take Risperdal and Diastat. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.
What is Risperdal?
Risperdal has active ingredients of risperidone. It is often used in bipolar disorder. eHealthMe is studying from 127,729 Risperdal users. Check the latest studies of Risperdal.
What is Diastat?
Diastat has active ingredients of diazepam. eHealthMe is studying from 2,104 Diastat users. Check the latest studies of Diastat.
47 people who take Risperdal and Diastat together, and have interactions are studied.

What are the common drug interactions of Risperdal and Diastat, by gender? *:
female:
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
- Gaze palsy (disorders affecting the ability to move both eyes in the same direction)
- Diarrhoea
- Aggression
- Drug level decreased
- Ear infection
- Weight increased
- Affective disorder (mental disorder)
- Anaemia (lack of blood)
- Anger
male:
- Allergy to arthropod sting
- Anaphylactic reaction (serious allergic reaction)
- Acute respiratory failure
- Breast hyperplasia (accumulation of abnormal cells in a breast duct)
- Ear infection
- Grand mal convulsion (a type of generalized seizure that affects the entire brain)
- Pneumonia
- Rash
- Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
- Respiratory distress (difficulty in breathing)
What are the common drug interactions of Risperdal and Diastat, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
- Gaze palsy (disorders affecting the ability to move both eyes in the same direction)
- Stomatitis (inflammation of mucous membrane of mouth)
- Breast hyperplasia (accumulation of abnormal cells in a breast duct)
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
- Drug level decreased
- Ear infection
- Rash
- Weight increased
- Acute respiratory failure
- Fall
10-19:
- Allergy to arthropod sting
- Anaphylactic reaction (serious allergic reaction)
- Suicide attempt
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
- Aggression
- Diarrhoea
- Schizoaffective disorder (a mental disorder characterized by disordered thought)
- Drug level decreased
- Grand mal convulsion (a type of generalized seizure that affects the entire brain)
- Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
20-29:
- Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
- Seizure (abnormal excessive or synchronous neuronal activity in the brain)
- Decreased activity
- Disturbance in attention
- Hypersensitivity
- Lethargy (tiredness)
- Muscle atrophy (a decrease in the mass of the muscle)
- Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
30-39:
- Anger
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
- Cough
- Drug level decreased
- Erythema of eyelid (redness of the eyelid)
- Eyelids pruritus (eyelids itching)
- Grand mal convulsion (a type of generalized seizure that affects the entire brain)
- Rhinorrhoea (watery mucus discharge from the nose)
- Snoring
- Aggression
40-49:
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
50-59:
n/a
60+:
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
- Concomitant disease progression (progress in accompanying disease)
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
- Drug level decreased
- Ear infection
- Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
- Pneumonia
- Weight increased
What are the existing conditions these people have? *
- Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 11 people, 23.40%
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 14.89%
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 7 people, 14.89%
- Tuberous Sclerosis (a rare genetic disease that causes benign tumours to grow in the brain and other organs): 6 people, 12.77%
- Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 12.77%
- Failure To Thrive (inadequate weight gain and physical growth in children): 6 people, 12.77%
- Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 5 people, 10.64%
- Abnormal Behavior: 4 people, 8.51%
- Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 3 people, 6.38%
- Salivary Hypersecretion (excess saliva secretion): 3 people, 6.38%
* Approximation only. Some reports may have incomplete information.
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Risperdal and Diastat:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Risperdal:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Diastat:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Risperdal and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Diastat and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Janardhana P, Nagaraj AK, Basavanna PL, "Risperidone-induced skin rash", Indian journal of psychiatry, 2016 Jan .
- Dsouza MC, "Could risperidone have caused the cataract?: A case report and review of literature", Journal of Research in Psychiatry and Behavioral Science, 2015 Jan .
- Dsouza MC, "COULD RISPERIDONE HAVE CAUSED THE CATARACT", JRPBS, 2015 Jan .
- Ray RK, Bashir MA, Rao S, "Co-Administration of Risperidone and Sodium Valproate Causing Bilateral Chronic Exertional Lower Leg Compartment Syndrome", Open Journal of Orthopedics, 2014 Apr .
- Hosseini, S. H., & Ahmadi, A., "Peripheral edema occurring during treatment with risperidone combined with citalopram", Case reports in medicine, 2012 Jan .
- Janardhana P, Nagaraj AK, Basavanna PL, "Risperidone-induced skin rash", Indian journal of psychiatry, 2016 Jan .
- Dsouza MC, "Could risperidone have caused the cataract?: A case report and review of literature", Journal of Research in Psychiatry and Behavioral Science, 2015 Jan .
- Dsouza MC, "COULD RISPERIDONE HAVE CAUSED THE CATARACT", JRPBS, 2015 Jan .
- Ray RK, Bashir MA, Rao S, "Co-Administration of Risperidone and Sodium Valproate Causing Bilateral Chronic Exertional Lower Leg Compartment Syndrome", Open Journal of Orthopedics, 2014 Apr .
- Hosseini, S. H., & Ahmadi, A., "Peripheral edema occurring during treatment with risperidone combined with citalopram", Case reports in medicine, 2012 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on risperidone and diazepam (the active ingredients of Risperdal and Diastat, respectively), and Risperdal and Diastat (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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