Risperdal and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Risperdal (risperidone) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include constipation among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Risperdal and Zosyn. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Risperdal?

Risperdal has active ingredients of risperidone. It is often used in bipolar disorder. eHealthMe is studying from 127,729 Risperdal users. Check the latest studies of Risperdal.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

On Jul, 12, 2026

62 people who take Risperdal and Zosyn together, and have interactions are studied.

What are the common drug interactions of Risperdal and Zosyn, by gender? *:

female:

Constipation
Pain in extremity
Death
Cellulitis (infection under the skin)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Delirium (wild excitement)
Pyrexia (fever)
Asthenia (weakness)
Cardiomegaly (increased size of heart than normal)
Confusional state

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pain
Pleural effusion (water on the lungs)
Renal failure (kidney dysfunction)
Bone marrow failure
Hypotension (abnormally low blood pressure)
Pyrexia (fever)
Rash

What are the common drug interactions of Risperdal and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

White blood cell count decreased

30-39:

Altered state of consciousness (altered state of mind)
Anaemia (lack of blood)
Blood glucose increased
Decreased appetite
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Electrocardiogram qt prolonged
Gastrointestinal mucosal disorder (disorder of gastrointestinal lining mucous membranes)
Generalised oedema (swelling all over the body)
Malignant neoplasm progression (cancer tumour came back)
Neuropathy peripheral (surface nerve damage)

40-49:

Hyperuricaemia (level of uric acid in the blood that is abnormally high)
Injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nasopharyngitis (inflammation of the nasopharynx)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Pulmonary embolism (blockage of the main artery of the lung)
Renal impairment (severely reduced kidney function)
Somnolence (a state of near-sleep, a strong desire for sleep)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
White blood cell count increased

50-59:

Neuropathy peripheral (surface nerve damage)
Back pain
Neutropenia (an abnormally low number of neutrophils)
Oesophageal carcinoma (cancer tumour of oesophagus)

60+:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Anxiety
Delirium (wild excitement)
Back pain
Bone disorder
Foot fracture
Mass
Osteoporosis (bones weak and more likely to break)
Swelling
Tooth loss

What are the existing conditions these people have? *

Sepsis (a severe blood infection that can lead to organ failure and death): 6 people, 9.68%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 6 people, 9.68%
Cancer Pain: 6 people, 9.68%
Pneumonia: 5 people, 8.06%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 6.45%
Insomnia (sleeplessness): 4 people, 6.45%
Diarrhea: 4 people, 6.45%
Delirium (wild excitement): 4 people, 6.45%
Acute Kidney Failure: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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