Risperidone and Artane drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Risperidone (risperidone) and Artane (trihexyphenidyl hydrochloride). Common drug interactions include diabetic gastroparesis among females and weight decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Risperidone and Artane. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Risperidone?

Risperidone has active ingredients of risperidone. It is often used in bipolar disorder. eHealthMe is studying from 72,175 Risperidone users. Check the latest studies of Risperidone.

What is Artane?

Artane has active ingredients of trihexyphenidyl hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 3,619 Artane users. Check the latest studies of Artane.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

98 people who take Risperidone and Artane together, and have interactions are studied.

Risperidone and Artane drug interactions.

What are the common drug interactions of Risperidone and Artane, by gender? *:

female:

Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Fatigue (feeling of tiredness)
Headache (pain in head)
Pain
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Abdominal pain upper
Anxiety
Blood oestrogen decreased

male:

Weight decreased
Constipation
Hallucination, auditory (perceiving sounds without auditory stimulus)
Heart rate increased
Impulsive behaviour
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Salivary hypersecretion (excess saliva secretion)
White blood cell count increased
Dizziness
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Risperidone and Artane, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Aggression
Head injury
Homicidal ideation (thoughts about human killing another human)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Psychomotor hyperactivity (feelings of extreme restlessness)
Self injurious behaviour

20-29:

Dyspnoea (difficult or laboured respiration)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Muscle disorder (muscle disease)
Asthenia (weakness)
Colon injury
Gastrointestinal injury (injury to gastrointestinal tract)
Nausea (feeling of having an urge to vomit)
Pharyngeal disorder
Traumatic lung injury
Visual impairment

30-39:

Delusion (a false belief or opinion)
Drug abuse
Mydriasis (a dilation of the pupil)
White blood cell count decreased
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood creatine phosphokinase increased
Blood prolactin increased

40-49:

Hallucination, auditory (perceiving sounds without auditory stimulus)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Weight increased
Abdominal pain upper
Blood oestrogen decreased
Blood triglycerides increased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Confusional state
Constipation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

50-59:

Decreased appetite
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Haematocrit decreased
Haemoglobin decreased
Heart rate increased
Impulsive behaviour
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Salivary hypersecretion (excess saliva secretion)

60+:

Pain
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Hypokalaemia (low potassium)
Acute respiratory failure
Agitation (state of anxiety or nervous excitement)
Delusion (a false belief or opinion)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Dizziness
Intentional self-injury
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 26 people, 26.53%
Stress And Anxiety: 20 people, 20.41%
Depression: 17 people, 17.35%
Psychotic Disorder: 9 people, 9.18%
High Blood Pressure: 9 people, 9.18%
Sleep Disorder: 6 people, 6.12%
Tardive Dyskinesia (a disorder that involves involuntary movements): 5 people, 5.10%
Insomnia (sleeplessness): 5 people, 5.10%

* Approximation only. Some reports may have incomplete information.

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