Risperidone and Epivir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Risperidone (risperidone) and Epivir (lamivudine). Common drug interactions include blood lactic acid increased among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Risperidone and Epivir. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Risperidone?

Risperidone has active ingredients of risperidone. It is often used in bipolar disorder. eHealthMe is studying from 72,175 Risperidone users. Check the latest studies of Risperidone.

What is Epivir?

Epivir has active ingredients of lamivudine. It is often used in hiv infection. eHealthMe is studying from 16,870 Epivir users. Check the latest studies of Epivir.



On Aug, 12, 2026

42 people who take Risperidone and Epivir together, and have interactions are studied.

Risperidone and Epivir drug interactions.

What are the common drug interactions of Risperidone and Epivir, by gender? *:

female:

  1. Blood lactic acid increased
  2. Blood magnesium decreased
  3. Blood pressure increased
  4. Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
  5. Depressed level of consciousness
  6. Diarrhoea
  7. Emotional disorder
  8. Hepatic function abnormal
  9. Hypocalcaemia (levels of calcium in blood serum are abnormally low)
  10. Hypokalaemia (low potassium)

male:

  1. Emotional distress
  2. Pain
  3. Exercise tolerance decreased
  4. Hypertension (high blood pressure)
  5. Renal impairment (severely reduced kidney function)
  6. Rib fracture
  7. Gait disturbance
  8. Mobility decreased (ability to move is reduced)
  9. Nephrogenic anaemia (anaemia due to kidney disease)
  10. Quality of life decreased

What are the common drug interactions of Risperidone and Epivir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  2. Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
  3. Hypotension (abnormally low blood pressure)
  4. Lactic acidosis (low ph in body tissues)
  5. Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  6. Oliguria (not enough urine)
  7. Pancreatitis (inflammation of pancreas)
  8. Pneumonia
  9. Renal tubular necrosis (death of kidney tubules)
  10. Respiratory distress (difficulty in breathing)

40-49:

  1. Pain
  2. Emotional distress
  3. Anxiety
  4. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  5. Chronic kidney disease
  6. Renal failure (kidney dysfunction)
  7. Bone density decreased
  8. Nephrogenic anaemia (anaemia due to kidney disease)
  9. Tooth loss
  10. Acetonaemia (acetone bodies in the blood)

50-59:

  1. Mobility decreased (ability to move is reduced)
  2. Osteoporosis (bones weak and more likely to break)
  3. Quality of life decreased
  4. Anaemia (lack of blood)
  5. Gait disturbance
  6. Sleep disorder
  7. Decreased activity
  8. Exercise tolerance decreased
  9. Foot fracture
  10. Impaired work ability

60+:

  1. Atrioventricular block complete (heart block complete)
  2. Blood pressure decreased
  3. Heart rate decreased
  4. Atrioventricular block (heart block)

What are the existing conditions these people have? *

  1. Hiv Infection: 33 people, 78.57%
  2. High Blood Pressure: 4 people, 9.52%
  3. High Blood Cholesterol: 4 people, 9.52%
  4. Acquired Immunodeficiency Syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv)): 4 people, 9.52%
  5. Persecutory Delusion: 3 people, 7.14%
  6. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.14%
  7. Depression: 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Risperidone and Epivir:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Risperidone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Epivir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Risperidone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Epivir and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on risperidone and lamivudine (the active ingredients of Risperidone and Epivir, respectively), and Risperidone and Epivir (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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